Evidence map›Paper›PMID 29213140›Full record

ReviewNature reviews. Cardiology2018

Effects of stress on the development and progression of cardiovascular disease.

Mika Kivimäki, Andrew Steptoe

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 537 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
537citing papers in PubMed, 7 pooled it
37.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06063174 nacompletednot on this mapstarted 2023, after this paper: background citation

Identifying Social, Molecular, & Immunological Processes for Mitigating Toxic Stress & Enhancing Personalized Resilience

TypeinterventionalSponsorUniversity of California, Los AngelesRan2023 to 2024Enrolled712ConditionsStress, Stress, Psychological, Stress, Physiological, Stress, EmotionalArmsEducation Program, Think Well Program, Be Well Program, Eat Well Program, Sleep Well Program
NCT06420817 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of a Customised Lifestyle Medicine Strategy on Lowering Blood Lipid Levels in Indian Physicians

TypeinterventionalSponsorJubilee Mission Medical College and Research InstituteRan2024 to 2024Enrolled50ConditionsLifestyle Risk Reduction, Cholesterol, Elevated, LDL Hyperlipoproteinemia, HypertensionArmsIndian version of a 'Portfolio' diet, Physical Activity, Intermittent fasting, Monitoring of sleep and stress levels
3 · Its place in the literature

Who cites it

537 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,141 citations in OpenAlex.

  1. Pooled it
  2. Physiological Responses to Virtual Reality-Based Stress Regulation and Relaxation Interventions: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
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  10. Effects of aJournal of psychopharmacology (Oxford, England) · 2025
    Trial
  11. Mood reactivity to daily social conflict in hostile adults: An experimental intervention.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Trial
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  19. Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome.International journal of molecular sciences · 2026
    Review
  20. Review

477 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
Andrew SteptoeResearch Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
University College London · GB

Funding

British Heart Foundation RG/16/11/32334Medical Research Council MR/K013351/1
6 · The paper itself

Abstract

Cardiovascular disease remains the leading cause of disease burden globally, which underlies the continuing need to identify new complementary targets for prevention. Over the past 5-10 years, the pooling of multiple data sets into 'mega-studies' has accelerated progress in research on stress as a risk and prognostic factor for cardiovascular disease. Severe stressful experiences in childhood, such as physical abuse and household substance abuse, can damage health and increase the risk of multiple chronic conditions in adulthood. Compared with childhood stress and adulthood classic risk factors, such as smoking, high blood pressure, and high serum cholesterol levels, the harmful effects of stress in adulthood are generally less marked. However, adulthood stress has an important role as a disease trigger in individuals who already have a high atherosclerotic plaque burden, and as a determinant of prognosis and outcome in those with pre-existing cardiovascular or cerebrovascular disease. In real-life settings, mechanistic studies have corroborated earlier laboratory-based observations on stress-related pathophysiological changes that underlie triggering, such as lowered arrhythmic threshold and increased sympathetic activation with related increases in blood pressure, as well as pro-inflammatory and procoagulant responses. In some clinical guidelines, stress is already acknowledged as a target for prevention for people at high overall risk of cardiovascular disease or with established cardiovascular disease. However, few scalable, evidence-based interventions are currently available.

Indexed as

Mental HealthAnimalsBrainCardiovascular DiseasesCardiovascular SystemDisease ProgressionHumansPrognosisRisk AssessmentRisk FactorsStress, Psychological

Identifiers

PMID29213140
OpenAlexW2773478070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.