Evidence map›Paper›PMID 29213060›Full record

ArticleScientific reports2017

Structural characterization of site-modified nanocapsid with monodispersed gold clusters.

Marie C Stark, Mo A Baikoghli, Tanja Lahtinen, Sami Malola, Li Xing, Michelle Nguyen, Marina Nguyen, Aria Sikaroudi, Varpu Marjomäki, Hannu Häkkinen and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Virus-like nanoparticles as a theranostic platform for cancer.Frontiers in bioengineering and biotechnology · 2022
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marie C StarkDepartment of Biology and Environmental Science, Nanoscience center, University of Jyväskylä, Jyväskylä, FI-40014, Finland.
Mo A BaikoghliDepartment of Molecular and Cellular Biology, University of California, Davis, CA, 95616, USA.
Tanja LahtinenDepartment of Chemistry, Nanoscience Center, University of Jyväskylä, Jyväskylä, FI-40014, Finland.
Sami MalolaDepartment of Physics, Nanoscience center, University of Jyväskylä, Jyväskylä, FI-40014, Finland.
Li XingDepartment of Biology and Environmental Science, Nanoscience center, University of Jyväskylä, Jyväskylä, FI-40014, Finland.
Michelle NguyenDepartment of Molecular and Cellular Biology, University of California, Davis, CA, 95616, USA.
Marina NguyenDepartment of Molecular and Cellular Biology, University of California, Davis, CA, 95616, USA.
Aria SikaroudiDepartment of Molecular and Cellular Biology, University of California, Davis, CA, 95616, USA.
Varpu MarjomäkiDepartment of Biology and Environmental Science, Nanoscience center, University of Jyväskylä, Jyväskylä, FI-40014, Finland.
Hannu HäkkinenDepartment of Chemistry, Nanoscience Center, University of Jyväskylä, Jyväskylä, FI-40014, Finland. hannu.j.hakkinen@jyu.fi.
R Holland ChengDepartment of Biology and Environmental Science, Nanoscience center, University of Jyväskylä, Jyväskylä, FI-40014, Finland. rhch@ucdavis.edu.

Funding

The rodent eye as a non-invasive window for understanding cancer nanotherapeuticsU01CA198880 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LAM, KIT S · 2015 to 2019
$2.9M
Genetically Encoded Small Illuminants for 4D nucleome imagingU01EB021230 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHENG, R.HOLLAND, IZUMIYA, YOSHIHIRO · 2015 to 2017
$990k
Present Homologous and Heterologous Antigen with Hepatitis E VirusR56AI095382 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHENG, R.HOLLAND · 2012 to 2012
$385k
NCI NIH HHS U01 CA198880NIAID NIH HHS R56 AI095382NIBIB NIH HHS U01 EB021230
6 · The paper itself

Abstract

Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the present study, the nanocapsid surface was modified with a solvent-exposed cysteine to conjugate monolayer protected gold nanoclusters (AuNC). Unlike commercially available gold nanoparticles, AuNCs monodisperse in water and are composed of a discrete number of gold atoms, forming a crystalline gold core. Au

Indexed as

Capsid ProteinsCryoelectron MicroscopyGoldHepatitis E virusMaleimidesMetal NanoparticlesMicroscopy, Electron, TransmissionRecombinant ProteinsCapsid ProteinsGoldmaleimideMaleimidesRecombinant Proteins

Identifiers

PMID29213060
PMCPMC5719084

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.