Evidence map›Paper›PMID 29213052›Full record

ArticleScientific reports2017

Exosomes from antigen-pulsed dendritic cells induce stronger antigen-specific immune responses than microvesicles in vivo.

Casper J E Wahlund, Gözde Güclüler, Stefanie Hiltbrunner, Rosanne E Veerman, Tanja I Näslund, Susanne Gabrielsson

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Does extracellular vesicle specificity truly exist?Cell communication and signaling : CCS · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Secretory exosomes from modified immune cells against cancer.Medical oncology (Northwood, London, England) · 2025
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Casper J E WahlundImmunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet KS L2:04, SE-17176, Stockholm, Sweden.
Gözde GüclülerImmunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet KS L2:04, SE-17176, Stockholm, Sweden.
Stefanie HiltbrunnerImmunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet KS L2:04, SE-17176, Stockholm, Sweden.
Rosanne E VeermanImmunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet KS L2:04, SE-17176, Stockholm, Sweden.
Tanja I NäslundImmunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet KS L2:04, SE-17176, Stockholm, Sweden.
Susanne GabrielssonImmunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet KS L2:04, SE-17176, Stockholm, Sweden. Susanne.Gabrielsson@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EV), including exosomes and microvesicles (MV), represent a rapidly expanding field of research with diagnostic and therapeutic applications. Although many aspects of EV function remain to be revealed and broad investigations are warranted, most published findings focus on only one vesicle category or a non-separated mix of EVs. In this paper, we investigated both MVs and exosomes from Ovalbumin (OVA)-pulsed dendritic cells for their immunostimulatory potential side-by-side in vivo. Only exosomes induced antigen-specific CD8

Indexed as

AnimalsAntigensB-LymphocytesBone Marrow CellsCD8-Positive T-LymphocytesCell-Derived MicroparticlesDendritic CellsExosomesImmunoglobulin GInterferon-gammaMiceMice, Inbred C57BLOvalbuminSpleenAntigensImmunoglobulin GInterferon-gammaOvalbumin

Identifiers

PMID29213052
PMCPMC5719080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.