ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2018
The Relationship between Neurite Density Measured with Confocal Microscopy in a Cleared Mouse Brain and Metrics Obtained from Diffusion Tensor and Diffusion Kurtosis Imaging.
Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Diffusion Tensor Imaging-Based Studies at the Group-Level Applied to Animal Models of Neurodegenerative Diseases.Frontiers in neuroscience · 2020Pooled it
- Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity.Journal of stroke · 2026Review
- Characterization of brain microstructural abnormalities in spasmodic dysphonia using diffusion kurtosis imaging.Scientific reports · 2025Article
- White matter changes in recovered COVID-19 patients: insights from DTI, DKI, and NODDI metrics.Frontiers in neurology · 2025Article
- Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure.PloS one · 2024Article
- Altered Cerebral Microstructure in Adults With Atrial Septal Defect and Ventricular Septal Defect Repaired in Childhood.Journal of the American Heart Association · 2022Observational
- Investigating the relationship between diffusion kurtosis tensor imaging (DKTI) and histology within the normal human brain.Scientific reports · 2021Article
- Diffusion kurtosis imaging of gray matter in young adults with autism spectrum disorder.Scientific reports · 2020Article
- Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome.Journal of neuroscience research · 2019Article
- Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDiffusional kurtosis imaging (DKI) enables sensitive measurement of tissue microstructure by quantifying the non-Gaussian diffusion of water. Although DKI is widely applied in many situations, histological correlation with DKI analysis is lacking. The purpose of this study was to determine the relationship between DKI metrics and neurite density measured using confocal microscopy of a cleared mouse brain.
methodsOne thy-1 yellow fluorescent protein 16 mouse was deeply anesthetized and perfusion fixation was performed. The brain was carefully dissected out and whole-brain MRI was performed using a 7T animal MRI system. DKI and diffusion tensor imaging (DTI) data were obtained. After the MRI scan, brain sections were prepared and then cleared using aminoalcohols (CUBIC). Confocal microscopy was performed using a two-photon confocal microscope with a laser. Forty-eight ROIs were set on the caudate putamen, seven ROIs on the anterior commissure, and seven ROIs on the ventral hippocampal commissure on the confocal microscopic image and a corresponding MR image. In each ROI, histological neurite density and the metrics of DKI and DTI were calculated. The correlations between diffusion metrics and neurite density were analyzed using Pearson correlation coefficient analysis.
resultsMean kurtosis (MK) (P = 5.2 × 10
conclusionDKI accurately reflected neurite density in the area with crossing fibers, potentially allowing evaluation of complex microstructures.
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