ArticleCirculation. Cardiovascular genetics2017
Genome-Wide Gene-Potassium Interaction Analyses on Blood Pressure: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity).
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Article in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults.Scientific reports · 2025Article
- Multi-omic analysis of human kidney tissue identified medulla-specific gene expression patterns.Kidney international · 2024Article
- Genomic Innovation in Early Life Cardiovascular Disease Prevention and Treatment.Circulation research · 2023Review
- Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population.Journal of the American Heart Association · 2022Article
- Advances in Genomics Research of Blood Pressure Responses to Dietary Sodium and Potassium Intakes.Hypertension (Dallas, Tex. : 1979) · 2021Review
- The effect of leptin on blood pressure considering smoking status: a Mendelian randomization study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Expanding congenital abnormalities of the kidney and urinary tract (CAKUT) genetics: basonuclin 2 (BNC2) and lower urinary tract obstruction.Annals of translational medicine · 2019Article
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Authors and funding
11 authors.
Changwei LiFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.). changwei.li@uga.edu.
Jiang HeFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Jing ChenFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Jinying ZhaoFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Dongfeng GuFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
James E HixsonFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Dabeeru C RaoFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Cashell E JaquishFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Treva K RiceFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Yun Ju SungFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Tanika N KellyFrom the Department of Epidemiology, Shool of Public Health and Tropical Medicine (C.L., J.H., J.C., T.N.K.), and Department of Medicine, School of Medicine (J.H., J.C.), Tulane University, New Orleans, LA; Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (C.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX (J.E.H.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R., Y.J.S.); and Division of Prevention and Population Sciences, National Heart, Lung, Blood Institute, Bethesda, MD (C.E.J.).
Funding
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MTulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Tanika Nicole Kelly · 2016 to 2026
$25.3MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MGenetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6MRare Variants for Hypertension in Taiwan ChineseR01HL111249 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2012 to 2015
$6.4MFamily-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureR01HL090682 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2008 to 2011
$2.8MSodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8MCigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0MAdjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3MSLEEP AND ENTRAINMENT OF SCN FUNCTIONR01HL064278 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STROHL, KINGMAN PERKINS · 1999 to 2002
$871kSUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694kNCRR NIH HHS UL1 RR024156NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01 HL111249NHLBI NIH HHS R01 HL118305NHLBI NIH HHS U01 HL072507NIGMS NIH HHS P20 GM109036
Abstract
backgroundGene-environmental interaction analysis can identify novel genetic factors for blood pressure (BP). We performed genome-wide analyses to identify genomic loci that interact with potassium to influence BP using single-marker (1 and 2 METHODS AND
resultsAmong 1876 GenSalt participants, the average of 3 urine samples was used to estimate potassium excretion. Nine BP measurements were taken using a random-zero sphygmomanometer. A total of 2.2 million single nucleotide polymorphisms were imputed using Affymetrix 6.0 genotype data and the Chinese Han of Beijing and Japanese of Tokyo HapMap reference panel. Promising findings (
conclusionsWe identified 2 novel BP loci and 6 genes through the examination of single nucleotide polymorphism- and gene-based interactions with potassium.
Indexed as
Genome-Wide Association StudyAdultAsian PeopleBlood PressureFemaleHumansMaleMiddle AgedMolecular EpidemiologyPotassiumPotassiumblood pressuregenome-wide association studygenotypepotassium
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