Trial reportJournal of the American Society of Nephrology : JASN2018
BP in Dialysis: Results of a Pilot Study.
Trial report in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Management of blood pressure in adults, children and young people on dialysis: UK kidney association clinical practice guideline.BMC nephrology · 2025Guideline
- Higher blood pressure targets for hypertension in older adults.The Cochrane database of systematic reviews · 2024Pooled it
- Left ventricular mass regression, all-cause and cardiovascular mortality in chronic kidney disease: a meta-analysis.BMC nephrology · 2022Pooled it
- Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2020Guideline
- Peridialysis BP levels and risk of all-cause mortality: a dose-response meta-analysis.Journal of human hypertension · 2019Pooled it
- I Brazilian guideline on hypertension in dialysis of the Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Dialysate Sodium Lowering in Maintenance Hemodialysis: A Randomized Clinical Trial.Clinical journal of the American Society of Nephrology : CJASN · 2024Trial
- A randomized controlled trial of two dialysate sodium concentrations in hospitalized hemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Trial
- Treating Home Versus Predialysis Blood Pressure Among In-Center Hemodialysis Patients: A Pilot Randomized Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Trial
- Emerging treatments and current strategies for mineral, vascular, and bone disorders in chronic kidney disease.World journal of nephrology · 2026Review
- Relationship between hypertension during dialysis and body composition in non-overweight/overweight obese patients.PloS one · 2026Article
- Operationalizing Home Blood Pressure Monitoring for Dialysis Patients: An Effectiveness-Implementation Hybrid Study.Kidney medicine · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Combined blood pressure and pulse rate as a new risk marker for mortality in hemodialysis patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Blood Pressure and Risk of Clinical Events in Peripheral Artery Disease.medRxiv : the preprint server for health sciences · 2025Article
- Volume Assessment in Patients Undergoing Long-Term Dialysis.Journal of the American Society of Nephrology : JASN · 2025Review
- Home versus routine dialysis-unit blood pressure recordings among patients on hemodialysis.Journal of human hypertension · 2025Article
- Observational
- Response to "Fine-Tuning Dry Weight: a Key Component in Managing Blood Pressure for Dialysis Patients".Kidney international reports · 2024Article
- Association of Calcium Channel Blocker Use With Intradialytic Hypotension in Maintenance Hemodialysis.Kidney international reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
The optimal BP target for patients receiving hemodialysis is unknown. We randomized 126 hypertensive patients on hemodialysis to a standardized predialysis systolic BP of 110-140 mmHg (intensive arm) or 155-165 mmHg (standard arm). The primary objectives were to assess feasibility and safety and inform the design of a full-scale trial. A secondary objective was to assess changes in left ventricular mass. Median follow-up was 365 days. In the standard arm, the 2-week moving average systolic BP did not change significantly during the intervention period, but in the intensive arm, systolic BP decreased from 160 mmHg at baseline to 143 mmHg at 4.5 months. From months 4-12, the mean separation in systolic BP between arms was 12.9 mmHg. Four deaths occurred in the intensive arm and one death occurred in the standard arm. The incidence rate ratios for the intensive compared with the standard arm (95% confidence intervals) were 1.18 (0.40 to 3.33), 1.61 (0.87 to 2.97), and 3.09 (0.96 to 8.78) for major adverse cardiovascular events, hospitalizations, and vascular access thrombosis, respectively. The intensive and standard arms had similar median changes (95% confidence intervals) in left ventricular mass of -0.84 (-17.1 to 10.0) g and 1.4 (-11.6 to 10.4) g, respectively. Although we identified a possible safety signal, the small size and short duration of the trial prevent definitive conclusions. Considering the high risk for major adverse cardiovascular events in patients receiving hemodialysis, a full-scale trial is needed to assess potential benefits of intensive hypertension control in this population.
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Registered trials
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