Evidence map›Paper›PMID 29212837›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2017

Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis.

Lisa H Lancaster, Joao A de Andrade, Joseph D Zibrak, Maria L Padilla, Carlo Albera, Steven D Nathan, Marlies S Wijsenbeek, John L Stauffer, Klaus-Uwe Kirchgaessler, Ulrich Costabel

Open access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 4 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 4 syntheses or guidelines pooled it, 273 citations in OpenAlex.

  1. Pooled it
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  15. SNX3 exacerbates hepatic fibrosis by amplifying TGF-Acta pharmaceutica Sinica. B · 2026
    Article
  16. Article
  17. Observational
  18. Review
  19. Pulmonary fibrosis: Emerging targets and novel therapeutics.The Journal of international medical research · 2026
    Review
  20. Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 5 countries.

Lisa H LancasterVanderbilt University Medical Center, Nashville, TN, USA lisa.lancaster@vanderbilt.edu.
Joao A de AndradeUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Joseph D ZibrakBeth Israel Deaconess Medical Center, Boston, MA, USA.
Maria L PadillaMount Sinai - National Jewish Health Respiratory Institute, New York, NY, USA.
Carlo AlberaUniversity of Turin, Turin, Italy.
Steven D NathanInova Fairfax Hospital, Falls Church, VA, USA.
Marlies S WijsenbeekErasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
John L StaufferGenentech, Inc., South San Francisco, CA, USA.
Klaus-Uwe KirchgaesslerF. Hoffmann-La Roche Ltd, Basel, Switzerland.
Ulrich CostabelRuhrlandklinik, University of Duisberg-Essen, Essen, Germany.
Beth Israel Deaconess Medical Center · USErasmus University Rotterdam · NLInova Fairfax Hospital · USNational Jewish Health · USRoche (Switzerland) · CHRuhrlandklinik · DEUniversity of Alabama at Birmingham · USUniversity of Turin · ITVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pirfenidone is one of two approved therapies for the treatment of idiopathic pulmonary fibrosis (IPF). Randomised controlled clinical trials and subsequent

Indexed as

Anti-Inflammatory Agents, Non-SteroidalDisease-Free SurvivalHumansIdiopathic Pulmonary FibrosisLungMedication AdherencePyridonesRecovery of FunctionRisk FactorsTime FactorsTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalpirfenidonePyridones

Identifiers

PMID29212837
PMCPMC9488585
OpenAlexW2774138788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.