Evidence map›Paper›PMID 29212834›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2017

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Corry-Anke Brandsma, Maaike de Vries, Rita Costa, Roy R Woldhuis, Melanie Königshoff, Wim Timens

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06736145 (Effects of Cervical Nags on Accessory Muscles in Patients With Copd), which is not on this map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06736145 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Cervical Nags on Accessory Muscles in Patients With Copd

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled36ConditionsCOPDArmsTraditional Physical Therapy, Mulligan Glides
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 219 citations in OpenAlex.

  1. Trial
  2. Dysregulated iron metabolism in remodeling of aging asthmatic human airways.American journal of physiology. Cell physiology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  15. β2-Microglobulin Induces Mitochondrial Dysfunction Accompanied by Bronchial Epithelial Cell Senescence.International journal of chronic obstructive pulmonary disease · 2026
    Article
  16. Article
  17. Article
  18. Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  19. Review
  20. Review

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Corry-Anke BrandsmaUniversity of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands c.a.brandsma@umcg.nl.
Maaike de VriesUniversity of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Rita CostaComprehensive Pneumology Center, Helmholtz Zentrum München, University Hospital of the Ludwig Maximilians University, Munich, Germany.
Roy R WoldhuisUniversity of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands.
Melanie KönigshoffComprehensive Pneumology Center, Helmholtz Zentrum München, University Hospital of the Ludwig Maximilians University, Munich, Germany.
Wim TimensUniversity of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands.
Ludwig-Maximilians-Universität München · DEUniversity Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes. A better understanding of the main differences and similarities between normal lung ageing and the pathology of COPD may improve our understanding of the mechanisms driving COPD pathology, in particular in those patients that develop the most severe form of COPD at a relatively young age,

Indexed as

Airway RemodelingCellular SenescenceRegenerationAdolescentAdultAgedAged, 80 and overAge FactorsAgingAnimalsChildFemaleGene Expression RegulationHumansLungMale

Identifiers

PMID29212834
PMCPMC9488745
OpenAlexW2772915294

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.