ArticleThe Journal of pharmacology and experimental therapeutics2018
Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model.
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Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Fenofibrate as a Modulator of the Renin-Angiotensin System in Su/Hx-Induced Pulmonary Arterial Hypertension.International journal of molecular sciences · 2025Article
- Sodium nitroprusside improves circulatory failure in rabbit acute pulmonary embolism combined with shock model possibly by enhancing NO release and inhibiting TLR4/NF-кB/HIF-1α signaling pathway.Frontiers in physiology · 2025Article
- Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation.Scientific reports · 2024Article
- Current Overview of the Biology and Pharmacology in Sugen/Hypoxia-Induced Pulmonary Hypertension in Rats.Journal of aerosol medicine and pulmonary drug delivery · 2024Review
- Pulmonary hypertension impairs vasomotor function in rat diaphragm arterioles.Microvascular research · 2024Article
- Pulmonary hypertension alters blood flow distribution and impairs the hyperemic response in the rat diaphragm.Frontiers in physiology · 2023Article
- Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models.Acta pharmacologica Sinica · 2022Article
- 3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.Matrix biology : journal of the International Society for Matrix Biology · 2022Article
- Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies.American journal of physiology. Heart and circulatory physiology · 2022Review
- Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstriction in Rodent Models.Oxidative medicine and cellular longevity · 2022Article
- Carbonic anhydrase inhibition improves pulmonary artery reactivity and nitric oxide-mediated relaxation in sugen-hypoxia model of pulmonary hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension.International journal of molecular sciences · 2021Article
- Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium-Dependent Hyperpolarization-Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension.Journal of the American Heart Association · 2020Article
- Noninvasive detection of impaired pulmonary artery endothelial function in people living with HIV.AIDS (London, England) · 2020Article
- miR-1 induces endothelial dysfunction in rat pulmonary arteries.Journal of physiology and biochemistry · 2019Article
- Tsantan Sumtang Alleviates Chronic Hypoxia-Induced Pulmonary Hypertension by Inhibiting Proliferation of Pulmonary Vascular Cells.BioMed research international · 2018Article
- Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia.Pulmonary circulationArticle
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Authors and funding
10 authors at 4 institutions in 2 countries.
Helen ChristouDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Hannes HudallaDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Zoe MichaelDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Evgenia J FilatavaDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Jun LiDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Minglin ZhuDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Jose S Possomato-VieiraDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Carlos Dias-JuniorDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Stella KourembanasDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.).
Raouf A KhalilDepartment of Pediatric Newborn Medicine (H.C., H.H., Z.M., E.J.F., S.K.), and Division of Vascular and Endovascular Surgery (J.L., M.Z., J.S.P.-V., C.D.-J., R.A.K.), Brigham and Women's Hospital, and Division of Newborn Medicine, Children's Hospital (H.C., S.K.), Harvard Medical School, Boston, Massachusetts; and Department of Neonatology, Children's University Hospital, Heidelberg, Germany (H.H.) raouf_khalil@hms.harvard.edu.
Harvard University · USHeidelberg University · DEBrigham and Women's Hospital · USUniversity Hospital Heidelberg · DE
Funding
HYPOXIC RESPONSES OF VASCULAR SMOOTH MUSCLER01HL055454 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI KOUREMBANAS, STELLA · 1996 to 2018
$6.7MVascular Mechanisms in Pregnancy-Induced HypertensionR01HL065998 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KHALIL, RAOUF A · 2002 to 2016
$4.3MVascular smooth muscle cell phenotypic switching in Pulmonary HypertensionR01HL116573 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHRISTOU, HELEN · 2014 to 2017
$1.7MNHLBI NIH HHS R01 HL055454NHLBI NIH HHS R01 HL065998NHLBI NIH HHS R01 HL116573
Abstract
Pulmonary vasoreactivity could determine the responsiveness to vasodilators and, in turn, the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and we examined the underlying mechanisms in the Sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with Sugen (20 mg/kg s.c.) and exposed to hypoxia (9% O
Indexed as
VasodilationAnimalsCell HypoxiaCyclic GMPDisease Models, AnimalHemodynamicsHypertension, PulmonaryMaleMuscle, Smooth, VascularNitric OxidePhenotypePulmonary ArteryRatsRats, Sprague-DawleySignal TransductionVascular RemodelingCyclic GMPNitric Oxide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.