Evidence map›Paper›PMID 29212815›Full record

ArticleThe EMBO journal2018

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Elena Purlyte, Herschel S Dhekne, Adil R Sarhan, Rachel Gomez, Pawel Lis, Melanie Wightman, Terina N Martinez, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 168 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 2 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 2 syntheses or guidelines pooled it, 362 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. LRRK2: Molecular Mechanisms in Parkinson's Disease.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Elucidating the molecular interplay between LRRK2 and Rab GTPases.bioRxiv : the preprint server for biology · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Lysosomal swelling triggers LRRK2 activity.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. ThemedRxiv : the preprint server for health sciences · 2025
    Article
  18. Article
  19. Review
  20. Article

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Elena PurlyteMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Herschel S DhekneDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
Adil R SarhanMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0000-0003-2163-4910
Rachel GomezDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
Pawel LisMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Melanie WightmanMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Terina N MartinezThe Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
Francesca TonelliMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK f.tonelli@dundee.ac.uk pfeffer@stanford.edu d.r.alessi@dundee.ac.uk.ORCID 0000-0002-4600-6630
Suzanne R PfefferDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA f.tonelli@dundee.ac.uk pfeffer@stanford.edu d.r.alessi@dundee.ac.uk.ORCID 0000-0002-6462-984X
Dario R AlessiMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK f.tonelli@dundee.ac.uk pfeffer@stanford.edu d.r.alessi@dundee.ac.uk.ORCID 0000-0002-2140-9185
University of Dundee · GBStanford University · USMichael J. Fox Foundation · US

Funding

INTRACELLULAR TRANSPORT--THE MANNOSE/PHOSPHATE RECEPTORR01DK037332 · NIDDK · STANFORD UNIVERSITY · PI PFEFFER, SUZANNE R · 1986 to 2019
$4.7M
INTRACELLULAR TRANSPORT--THE MANNOSE-PHOSPHATE RECEPTORR37DK037332 · NIDDK · STANFORD UNIVERSITY · PI PFEFFER, SUZANNE R · 1999 to 2008
$3.4M
Intracellular Transport-The Mannose Phosphate ReceptorR56DK037332 · NIDDK · STANFORD UNIVERSITY · PI PFEFFER, SUZANNE R · 2014 to 2014
$120k
Medical Research Council MC_UU_00018/1Medical Research Council MC_UU_12016/2NIDDK NIH HHS R01 DK037332NIDDK NIH HHS R37 DK037332NIDDK NIH HHS R56 DK037332
6 · The paper itself

Abstract

Parkinson's disease predisposing LRRK2 kinase phosphorylates a group of Rab GTPase proteins including Rab29, within the effector-binding switch II motif. Previous work indicated that Rab29, located within the PARK16 locus mutated in Parkinson's patients, operates in a common pathway with LRRK2. Here, we show that Rab29 recruits LRRK2 to the

Indexed as

AnimalsCells, CulturedCRISPR-Cas SystemsFibroblastsHEK293 CellsHeLa CellsHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMice, Inbred C57BLParkinson DiseasePhosphorylationrab1 GTP-Binding Proteinsrab GTP-Binding ProteinsSignal TransductionLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanrab1 GTP-Binding ProteinsRab29 protein, humanrab GTP-Binding ProteinsGolgiGTPasePARK genesphosphorylationRab10

Identifiers

PMID29212815
PMCPMC5753036
OpenAlexW2771688344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.