Evidence map›Paper›PMID 29212791›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice.

Markus Velten, Kathryn M Heyob, Loren E Wold, Lynette K Rogers

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Perinatal Inflammation Results in Sex-Dependent Cardiac Dysfunction.Journal of cardiovascular development and disease · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Hemodynamic assessment of diastolic function for experimental models.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Markus VeltenDepartment of Anesthesiology and Intensive Care Medicine, Rheinische Friedrich Wilhelms University, University Medical Center , Bonn , Germany.
Kathryn M HeyobCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University , Columbus, Ohio.
Loren E WoldThe Ohio State University , Columbus, Ohio.
Lynette K RogersCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University , Columbus, Ohio.
Nationwide Children's Hospital · USThe Ohio State University · USUniversity of Bonn · DE

Funding

Synergistic effects of obesity and air pollution on cardiac functionR01ES019923 · NIEHS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WOLD, LOREN EUGENE · 2011 to 2015
$1.8M
DHA attenuates Inflammatory Responses Through Altering RAGE SignalingR01AT006880 · NCCIH · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ROGERS, LYNETTE KAY · 2011 to 2015
$1.8M
NCCIH NIH HHS R01 AT006880NIEHS NIH HHS R01 ES019923
6 · The paper itself

Abstract

Sex-related differences in cardiovascular health and disease have been identified, with males having a higher incidence of cardiovascular events but females more likely to develop arrhythmias. Adverse fetal environments are now accepted as a cause for the development of cardiovascular diseases in adulthood, but sex-related differences in response to adverse fetal environments have not been extensively explored. The combination of both in utero and postnatal exposure to inflammation is highly relevant for the infant that is born preterm or has clinical complications at birth or in early postnatal life. We have previously observed cardiac contractile deficiencies and dysregulation of Ca

Indexed as

Pregnancy ComplicationsPrenatal Exposure Delayed EffectsAnimalsAnimals, NewbornCardiomyopathiesConnexin 43DesminDisease Models, AnimalFemaleHeart RateHyperoxiaInflammationLipopolysaccharidesMaleMiceMicroRNAsConnexin 43DesminGJA1 protein, mouselipopolysaccharide, Escherichia coli O111 B4LipopolysaccharidesMicroRNAsMirn208 microRNA, mouseMyh6 protein, mouseMyosin Heavy Chainsdesminmicroribonucleic acid 208myosin heavy chain

Identifiers

PMID29212791
PMCPMC5899262
OpenAlexW2771208379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.