Evidence map›Paper›PMID 29212769›Full record

ArticleAmerican journal of physiology. Cell physiology2018

Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β

Claudio F Perez, Jose M Eltit, Jose R Lopez, Dóra Bodnár, Angela F Dulhunty, Shouvik Aditya, Marco G Casarotto

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Claudio F PerezDepartment of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.
Jose M EltitDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University , Richmond, Virginia.
Jose R LopezDepartment of Molecular Biosciences, University of California , Davis, California.
Dóra BodnárDepartment of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.
Angela F DulhuntyJohn Curtin School of Medical Research, Australian National University , Canberra , Australia.
Shouvik AdityaJohn Curtin School of Medical Research, Australian National University , Canberra , Australia.
Marco G CasarottoJohn Curtin School of Medical Research, Australian National University , Canberra , Australia.
Australian National University · AUBrigham and Women's Hospital · USHarvard University · USUniversity of California, Davis · USVirginia Commonwealth University · US

Funding

Structural and molecular requirements for DHPR and RyR1 bidirectional signalingR01AR067738 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PEREZ, CLAUDIO F · 2016 to 2020
$2.3M
Ca2+ regulation in muscle by a new class of Ca2+-binding domain of RyRsR03AR066359 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PEREZ, CLAUDIO F · 2014 to 2016
$258k
NIAMS NIH HHS R01 AR067738NIAMS NIH HHS R03 AR066359
6 · The paper itself

Abstract

Malignant hyperthermia (MH) susceptibility has been recently linked to a novel variant of β

Indexed as

Calcium SignalingAnimalsCaffeineCalciumCalcium Channels, L-TypeCells, CulturedDose-Response Relationship, DrugHomozygoteHumansKineticsMalignant HyperthermiaMice, KnockoutMutationMyoblastsProtein DomainsProtein StabilityCacnb1 protein, mouseCaffeineCalciumCalcium Channels, L-TypeCa2+ currentsCa2+ releasecaffeine sensitivityprotein stabilityresting Ca2+ concentration

Identifiers

PMID29212769
PMCPMC6335014
OpenAlexW2774986343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.