ArticleStroke2018
Astrocytic Lrp4 (Low-Density Lipoprotein Receptor-Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A
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Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 42 citations in OpenAlex.
- Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury.CNS neuroscience & therapeutics · 2026Review
- Article
- Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential.Frontiers in pharmacology · 2025Review
- Astrocyte Regulation of Neuronal Function and Survival in Stroke Pathophysiology.Advances in neurobiology · 2024Review
- Caffeine and Its Neuroprotective Role in Ischemic Events: A Mechanism Dependent on Adenosine Receptors.Cellular and molecular neurobiology · 2022Review
- Ectoderm-derived frontal bone mesenchymal stem cells promote traumatic brain injury recovery by alleviating neuroinflammation and glutamate excitotoxicity partially via FGF1.Stem cell research & therapy · 2022Article
- Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage.Cellular and molecular life sciences : CMLS · 2022Article
- Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury.Cell death & disease · 2022Article
- Adenosine A2A Receptor Suppressed Astrocyte-Mediated Inflammation Through the Inhibition of STAT3/YKL-40 Axis in Mice With Chronic Cerebral Hypoperfusion-induced White Matter Lesions.Frontiers in immunology · 2022Article
- Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Article
- Crosstalk Between ATP-PFrontiers in cellular neuroscience · 2021Article
- Fibroblast growth factor 2 upregulates ecto-5'-nucleotidase and adenosine deaminase via MAPK pathways in cultured rat spinal cord astrocytes.Purinergic signalling · 2020Article
- NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice.Journal of neuroinflammation · 2020Article
- Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice.Journal of neuroinflammation · 2020Article
- Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine ABritish journal of pharmacology · 2019Article
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Authors and funding
11 authors at 1 institution in 1 country.
Xin-Chun YeFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Jin-Xia HuFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Lei LiFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Qiang LiFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Fu-Lei TangFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Sen LinFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Dong SunFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Xiang-Dong SunFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Gui-Yun CuiFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Lin MeiFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.).
Wen-Cheng XiongFrom the Department of Neuroscience and Regenerative Medicine (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.) and Department of Neurology (X.-C.Y., J.-X.H., L.L., Q.L., F.-L.T., S.L., D.S., X.-D.S., L.M., W.-C.X.), Medical College of Georgia, Augusta University; Institute of Nervous System Diseases (X.-C.Y., J.-X.H.) and Department of Neurology, The Affiliated Hospital of Xuzhou Medical University (X.-C.Y., J.-X.H., G.-Y.C.), Xuzhou Medical University, Jiangsu, China; and Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun (Q.L.). wxiong@augusta.edu.
Xuzhou Medical College · CN
Funding
Mechanisms of neuromuscular junction formationR01NS082007 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2013 to 2022
$5.2MNRG1-ErbB4 regulation of synaptic plasticity and behaviorR01MH083317 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2008 to 2018
$4.3MCharacterization of Agrin/LRP4 Antibody-Positive Myasthenia GravisR01NS090083 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2015 to 2019
$2.9MSwedish APP mutation and NMJ decline in Alzheimer's diseaseRF1AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2020 to 2020
$2.6MSwedish APP mutation and NMJ decline in Alzheimer's diseaseR01AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2015 to 2024
$2.6MRetromer deficiency and Alzheimer's disease pathologyRF1AG045781 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2019 to 2019
$2.0MAPP as a common denominator for Alzheimer's disease and osteoporosisR01AG051773 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2016 to 2020
$2.0MRetromer deficiency and Alzheimer's disease pathologyR01AG045781 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2014 to 2017
$1.7MNIA NIH HHS R01 AG045781NIA NIH HHS R01 AG051510NIA NIH HHS R01 AG051773NIA NIH HHS RF1 AG045781NIA NIH HHS RF1 AG051510NIMH NIH HHS R01 MH083317NINDS NIH HHS R01 NS082007NINDS NIH HHS R01 NS090083
Abstract
background and purposeLrp4 (low-density lipoprotein receptor-related protein 4) is predominantly expressed in astrocytes, where it regulates glutamatergic neurotransmission by suppressing ATP release. Here, we investigated Lrp4's function in ischemia/stroke-induced brain injury response, which includes glutamate-induced neuronal death and reactive astrogliosis.
methodsThe brain-specific Lrp4 conditional knockout mice (Lrp4
resultsLrp4, largely expressed in astrocytes, was increased in response to ischemia/stroke. Both Lrp4
conclusionsThe astrocytic Lrp4 plays an important role in ischemic brain injury response. Lrp4 deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A
Indexed as
Signal TransductionAdenosine TriphosphateAnimalsAstrocytesBrain InjuriesBrain IschemiaLDL-Receptor Related ProteinsMiceMice, KnockoutReceptor, Adenosine A2AReceptors, LDLReceptors, Purinergic P2X7Adenosine TriphosphateLDL-Receptor Related ProteinsLrp4 protein, mouseReceptor, Adenosine A2AReceptors, LDLReceptors, Purinergic P2X7adenosineastrocytesbrain injuryischemiareceptor, adenosine A2A
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