Evidence map›Paper›PMID 29212662›Full record

ArticleGenes & development2017

Sharing the load: Mex67-Mtr2 cofunctions with Los1 in primary tRNA nuclear export.

Kunal Chatterjee, Shubhra Majumder, Yao Wan, Vijay Shah, Jingyan Wu, Hsiao-Yun Huang, Anita K Hopper

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Gle1 is required for tRNA to stimulate Dbp5 ATPase activitybioRxiv : the preprint server for biology · 2023
    Article
  7. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  8. Article
  9. A Simple Method for the Detection of Wybutosine-Modified tRNAMethods in molecular biology (Clifton, N.J.) · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Therapeutic promise of engineered nonsense suppressor tRNAs.Wiley interdisciplinary reviews. RNA · 2021
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kunal ChatterjeeThe Ohio State University Comprehensive Cancer Research Center, The Ohio State University, Columbus, Ohio 43210, USA.
Shubhra MajumderDepartment of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
Yao WanThe Ohio State University Comprehensive Cancer Research Center, The Ohio State University, Columbus, Ohio 43210, USA.
Vijay ShahDepartment of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
Jingyan WuThe Ohio State University Comprehensive Cancer Research Center, The Ohio State University, Columbus, Ohio 43210, USA.
Hsiao-Yun HuangDepartment of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
Anita K HopperDepartment of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.ORCID 0000-0002-7884-2932
The Ohio State University · US

Funding

YEAST GENES IN RNA PROCESSING &NUCLEUS/CYTOSOL EXCHANGER01GM027930 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HOPPER, ANITA K · 1985 to 2014
$4.6M
tRNA processing and nuclear-cytoplasmic dynamicsR01GM122884 · NIGMS · OHIO STATE UNIVERSITY · PI HOPPER, ANITA K · 2017 to 2024
$2.7M
NIGMS NIH HHS R01 GM027930NIGMS NIH HHS R01 GM122884
6 · The paper itself

Abstract

Eukaryotic transfer RNAs (tRNAs) are exported from the nucleus, their site of synthesis, to the cytoplasm, their site of function for protein synthesis. The evolutionarily conserved β-importin family member Los1 (Exportin-t) has been the only exporter known to execute nuclear export of newly transcribed intron-containing pre-tRNAs. Interestingly,

Indexed as

Active Transport, Cell NucleusGene SilencingMembrane Transport ProteinsNuclear Pore Complex ProteinsNuclear ProteinsNucleocytoplasmic Transport ProteinsProtein BindingProteomeRNA-Binding ProteinsRNA, TransferSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsLos1 protein, S cerevisiaeMembrane Transport ProteinsMEX67 protein, S cerevisiaeMtr2 protein, S cerevisiaeNuclear Pore Complex ProteinsNuclear ProteinsNucleocytoplasmic Transport ProteinsProteomeRNA-Binding ProteinsRNA, TransferSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiaetRNA subcellular dynamicstRNA trafficking

Identifiers

PMID29212662
PMCPMC5749166
OpenAlexW2772524073

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.