ArticleComparative medicine2017
Mice Housed at Elevated Vivarium Temperatures Display Enhanced T-cell Response and Survival to
Article in Comparative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Article
- Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19.The Science of the total environment · 2023Article
- Temperature control in sepsis.Frontiers in medicine · 2023Review
- How murine models of human disease and immunity are influenced by housing temperature and mild thermal stress.Temperature (Austin, Tex.) · 2023Review
- Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility.Animals : an open access journal from MDPI · 2022Review
- Thermoneutral Housing Temperature Improves Survival in a Murine Model of Polymicrobial Peritonitis.Shock (Augusta, Ga.) · 2020Article
- Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery.BMC immunology · 2020Review
- Effects of Propranolol on Bone, White Adipose Tissue, and Bone Marrow Adipose Tissue in Mice Housed at Room Temperature or Thermoneutral Temperature.Frontiers in endocrinology · 2020Article
- Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?Frontiers in immunology · 2020Review
- Effects of Social Housing Changes on Immunity and Vaccine-Specific Immune Responses in Adolescent Male Rhesus Macaques.Frontiers in immunology · 2020Article
- Thermoneutral housing attenuates premature cancellous bone loss in male C57BL/6J mice.Endocrine connections · 2019Article
- Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Effects of Rodent Thermoregulation on Animal Models in the Research Environment.Comparative medicine · 2018Review
- Hepatitis A Virus Infection in Cynomolgus Monkeys Confounds the Safety Evaluation of a Drug Candidate.International journal of toxicologyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inability to translate findings from studies performed in mouse models to the corresponding human condition is well known, especially those involving infectious, atherosclerotic, and other inflammatory diseases. We hypothesize that mice fail to a mount robust or adequate immune response to infectious agents because of physiologic effects of cold stress due to housing temperatures below the mouse thermoneutral zone (TNZ). This hypothesis was tested by comparing the immune response to the Francisella tularensis live vaccine strain in mice housed at a typical vivarium temperature, which is below the TNZ, with that of mice housed at a temperature near their TNZ. Mice maintained at 28 °C displayed elevated antigen-specific T-cell responses compared with mice housed at 22 °C and survived intranasal challenge that was fatal to immunized mice at 22 °C. These results demonstrate that cold stress due to housing below the mouse TNZ results in a blunted immune response and may compromise their translational value a models for infectious diseases and vaccine development.
Indexed as
Identifiers
29212580PMC5713163What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.