Evidence map›Paper›PMID 29212559›Full record

ArticleDevelopment and psychopathology2018

The body remembers: Adolescent conflict struggles predict adult interleukin-6 levels.

Joseph P Allen, Emily L Loeb, Joseph S Tan, Rachel K Narr, Bert N Uchino

Abstract read
In one paragraph

Article in Development and psychopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Predictions from early adolescent interpersonal aggression to accelerated aging in adulthood: Relational and biological mechanisms of linkage.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  2. Article
  3. Review
  4. Adolescent social learning within supportive friendships: Self-disclosure and relationship quality from adolescence to adulthood.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2024
    Article
  5. Article
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  11. Impact of the COVID-19 pandemic on inflammatory bowel disease: The role of emotional stress and social isolation.Stress and health : journal of the International Society for the Investigation of Stress · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph P AllenUniversity of Virginia.
Emily L LoebUniversity of Virginia.
Joseph S TanUniversity of Virginia.
Rachel K NarrUniversity of Virginia.
Bert N UchinoUniversity of Utah.

Funding

Social Relationship Qualities as Predictors of Health & Aging from Adolescence through Mid-AdulthoodR37HD058305 · NICHD · UNIVERSITY OF VIRGINIA · PI JOSEPH Patrick ALLEN · 2018 to 2026
$6.1M
Adolescent Peer and Family Relationship Predictors of Adult HealthR01HD058305 · NICHD · UNIVERSITY OF VIRGINIA · PI ALLEN, JOSEPH PATRICK · 2008 to 2017
$5.4M
FAMILY CONTEXTS OF DEVELOPING ADOLESCENT PEER RELATIONSR01MH058066 · NIMH · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ALLEN, JOSEPH PATRICK · 1998 to 2007
$3.7M
NICHD NIH HHS R01 HD058305NICHD NIH HHS R37 HD058305NIMH NIH HHS R01 MH058066
6 · The paper itself

Abstract

Struggles managing conflict and hostility in adolescent social relationships were examined as long-term predictors of immune-mediated inflammation in adulthood that has been linked to long-term health outcomes. Circulating levels of interleukin-6 (IL-6), a marker of immune system dysfunction when chronically elevated, were assessed at age 28 in a community sample of 127 individuals followed via multiple methods and reporters from ages 13 to 28. Adult serum IL-6 levels were predicted across periods as long as 15 years by adolescents' inability to defuse peer aggression and poor peer-rated conflict resolution skills, and by independently observed romantic partner hostility in late adolescence. Adult relationship difficulties also predicted higher IL-6 levels but did not mediate predictions from adolescent-era conflict struggles. Predictions were also not mediated by adult trait hostility or aggressive behavior, suggesting the unique role of struggles with conflict and hostility from others during adolescence. The implications for understanding the import of adolescent peer relationships for life span physical health outcomes are considered.

Indexed as

HostilityInterpersonal RelationsPeer GroupAdolescentAdultAggressionFemaleHumansInterleukin-6MaleYoung AdultInterleukin-6

Identifiers

PMID29212559
PMCPMC5991989

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.