ArticleCritical care (London, England)2017
Extracorporeal membrane oxygenation for life-threatening asthma refractory to mechanical ventilation: analysis of the Extracorporeal Life Support Organization registry.
Article in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of extracorporeal COCritical care (London, England) · 2024Pooled it
- Extracorporeal Life Support in Pregnancy: A Systematic Review.Journal of the American Heart Association · 2020Pooled it
- Respiratory Support in Pediatric Critical and Near-Fatal Asthma: A Narrative Review.Pulmonary therapy · 2026Review
- Veno-Venous Extracorporeal Membrane Oxygenation as Rescue Therapy for Near-Fatal Asthma: A Case Report.Cureus · 2026Article
- Article
- Article
- Characteristics and Outcomes of Patients Receiving Volatile Anesthetics in Near-Fatal Asthma: A Retrospective Observational Cohort Study.Critical care explorations · 2025Observational
- Management of Asthma and COPD Exacerbations in Adults in the ICU.CHEST critical care · 2025Article
- Extracorporeal membrane oxygenation for adults with respiratory failure secondary to cardiorespiratory disease: evolving indications and clinical practice.Breathe (Sheffield, England) · 2025Review
- Short-Term Neurologic Complications in Patients Undergoing Extracorporeal Membrane Oxygenation Support: A Review on Pathophysiology, Incidence, Risk Factors, and Outcomes.Pulmonary therapy · 2024Review
- Is there still a place for ECCOMedizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Extracorporeal Membrane Oxygenation for Respiratory Failure: A Narrative Review.Journal of clinical medicine · 2024Review
- Outcomes of Extracorporeal Life Support (ECLS) in Acute Severe Asthma: A Narrative Review.Lung · 2024Review
- Evidence Synthesis of Outcomes of Extracorporeal Membrane Oxygenation for Life-Threatening Asthma Exacerbations.CHEST critical care · 2024Article
- Critical Care Management of Severe Asthma Exacerbations.Journal of clinical medicine · 2024Review
- Use of venovenous (VV) extracorporeal membrane oxygenation (ECMO) in near-fatal asthma: a case series.Multidisciplinary respiratory medicine · 2024Article
- VV-ECMO as bridge and safety net for successful therapeutic polypragmasy in a case of influenza-triggered near-fatal asthma.Clinical case reports · 2023Article
- Extracorporeal Membrane Oxygenation in Acute Respiratory Failure.Pulmonary therapy · 2023Review
- Single-institution experience of extracorporeal membrane oxygenation for near-fatal asthma.Respiratory medicine case reports · 2023Article
- Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure.Chest · 2023Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of extracorporeal membrane oxygenation (ECMO) in cases of near-fatal asthma (NFA) has increased, but the benefits and potential complications of this therapy have yet to be fully investigated.
methodsCases were extracted from the Extracorporeal Life Support Organization Registry between March 1992 and March 2016. All patients with a diagnosis of asthma (according to the International Classification of Diseases 9th edition), who also received ECMO, were extracted. Exclusion criteria included patients who underwent multiple courses of ECMO; those who received ECMO for cardiopulmonary resuscitation or cardiac dysfunction; and those with another primary diagnosis, such as sepsis. We analyzed survival to hospital discharge, complications, and clinical factors associated with in-hospital mortality, in patients with severe life-threatening NFA requiring ECMO support.
resultsIn total 272 patients were included. The mean time spent on ECMO was 176.4 hours. Ventilator settings, including rate, fraction of inspired oxygen (FiO
conclusionsECMO can provide adequate gas exchange and prevent lung injury induced by mechanical ventilation, and may be an effective bridging strategy to avoid aggressive ventilation in refractory NFA. However, careful management is required to avoid complications.
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Registered trials
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