Trial reportCritical care (London, England)2017
A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 hours in critically ill patients.
Trial report in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Early vs Late Supplemental ParenteraL Nutrition on Long-term Quality of Life in ICU Patients After Gastrointestinal Oncological Surgery. A Prospective, Randomised, Multi-centre Assessor-blinded Study. hELPLiNe Trial
Amino Acid Effluent Loss During Continuous Renal Replacement Therapy: an Explorative Non-interventional Pilot Study
Who cites it
8 citing papers in PubMed, 35 citations in OpenAlex.
- Trial
- Influence of intravenous 10% amino acids infusion on serum albumin concentration in hypoalbuminemic dogs.Frontiers in veterinary science · 2023Article
- Postprandial rise of essential amino acids is impaired during critical illness and unrelated to small-intestinal function.JPEN. Journal of parenteral and enteral nutrition · 2022Article
- Skeletal muscle depletion and nutrition support affected postoperative complications in patients who underwent pancreatoduodenectomy.European journal of clinical nutrition · 2021Article
- Article
- Metabolic support in the critically ill: a consensus of 19.Critical care (London, England) · 2019Review
- Response to Gunst and Casaer on the letter to the editor "Is the protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?"Critical care (London, England) · 2018Article
- Route, early or energy? … Protein improves protein balance in critically ill patients.Critical care (London, England) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundProviding supplemental amino acids to ICU patients during a 3-h period results in improved whole-body net protein balance, without an increase in amino acid oxidation. The primary objective was to investigate if a 24-h intravenous amino acid infusion in critically ill patients has a sustained effect on whole-body protein balance as was seen after 3 h. Secondary objectives were monitoring of amino acid oxidation rate, urea and free amino acid plasma concentrations.
methodsAn infusion of [1-
resultsEight patients were studied. The amino acid infusion resulted in improved net protein balance over time, from -1.6 ± 7.9 μmol phe/kg/h at 0 h to 6.0 ± 8.8 at 3 h and 7.5 ± 5.1 at 24 h (p = 0.0016). The sum of free amino acids in plasma increased from 3.1 ± 0.6 mmol/L at 0 h to 3.2 ± 0.3 at 3 h and 3.6 ± 0.5 at 24 h (p = 0.038). Amino acid oxidation and plasma urea were not altered significantly.
conclusionWe demonstrated that the improvement in whole-body net protein balance from a supplemental intravenous amino acid infusion seen after 3 h was sustained after 24 h in critically ill patients.
trial registrationThis trial was prospectively registered at Australian New Zealand Clinical Trials Registry. ACTRN, 12615001314516 . Registered on 1 December 2015.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.