ArticleAlzheimer's research & therapy2017
Anemia is associated with incidence of dementia: a national health screening study in Korea involving 37,900 persons.
Article in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 98 citations in OpenAlex.
- Body mass index levels and changes before and after dementia diagnosis and risk of all-cause mortality: a nationwide cohort study.Alzheimer's research & therapy · 2026Article
- Bidirectional relationship between anemia and cognitive function in middle-aged and older Chinese adults: a longitudinal study.Scientific reports · 2025Article
- Alzheimer Disease in Breast Cancer Survivors.JAMA network open · 2025Article
- Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study.Scientific reports · 2024Article
- Article
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- Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer's disease: A population-based nested case-control study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Anemia-associated smaller brain volume and sex differences: a cross-sectional study of magnetic resonance imaging in brain health checkups.Frontiers in aging neuroscience · 2024Article
- Association between hemoglobin trajectories and the incidence of dementia in a cohort of females aged 55-79 years.PloS one · 2024Article
- Low HALP (Hemoglobin, Albumin, Lymphocyte, and Platelet) Score Increases the Risk of Post-Stroke Cognitive Impairment: A Multicenter Cohort Study.Clinical interventions in aging · 2024Article
- Causal feature selection using a knowledge graph combining structured knowledge from the biomedical literature and ontologies: A use case studying depression as a risk factor for Alzheimer's disease.Journal of biomedical informatics · 2023Article
- Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study.Alzheimer's research & therapy · 2023Article
- Changes in Alcohol Consumption and Risk of Dementia in a Nationwide Cohort in South Korea.JAMA network open · 2023Article
- Association of Changes in Smoking Intensity With Risk of Dementia in Korea.JAMA network open · 2023Article
- Association of Anemia with Cognitive Function and Dementia Among Older Adults: The Role of Inflammation.Journal of Alzheimer's disease : JAD · 2023Article
- Association of late-life body mass index with the risk of Alzheimer disease: a 10-year nationwide population-based cohort study.Scientific reports · 2022Article
- Association between visit-to-visit blood pressure variability and risks of dementia in CKD patients: a nationwide observational cohort study.Clinical kidney journal · 2022Article
- Health Benefits of Apple Juice Consumption: A Review of Interventional Trials on Humans.Nutrients · 2022Review
- Deep phenotyping of Alzheimer's disease leveraging electronic medical records identifies sex-specific clinical associations.Nature communications · 2022Article
- Augmented risk of dementia in hypertrophic cardiomyopathy: A propensity score matching analysis using the nationwide cohort.PloS one · 2022Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe aim of this study was to investigate whether anemia is associated with dementia incidence in the elderly.
methodsUsing the Korean National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) database, we identified 66-year-old subjects (n = 37,900) who were free of dementia and stroke. Anemia (hemoglobin < 12 g/dl for women and < 13 g/dl for men) and the severity of anemia (mild, moderate, or severe) were defined using World Health Organization criteria. The incidence of dementia was identified using International Classification of Diseases, Tenth Revision, dementia diagnosis codes (F00, F01, F02, F03, and G30) with prescription of an antidementia drug. Cox proportional hazards regression models were used to assess HRs for dementia incidence according to anemia.
resultsAfter adjusting for sex, baseline cognitive state, body mass index, smoking status, household income, disability, depression, hypertension, diabetes, and dyslipidemia, we found a significant association between anemia and dementia incidence (adjusted HR 1.24; 95% CI 1.02-1.51). The adjusted HRs for incidence of dementia according to the severity of anemia were 1.19 (95% CI 0.98-1.45) for those with mild anemia, 1.47 (95% CI 0.97-2.21) for those with moderate anemia, and 5.72 (95% CI 1.84-17.81) for those with severe anemia, showing a significant p value for trend (p = 0.003).
conclusionsAnemia is an independent risk factor for dementia incidence, with a marked increase of risk associated with severe anemia.
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