ArticleBMC research notes2017
Structural and functional annotation of hypothetical proteins of human adenovirus: prioritizing the novel drug targets.
Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
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- Structure based functional identification of an uncharacterized protein from Coxiella burnetii involved in adipogenesis.Scientific reports · 2024Article
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- In silico analysis of a novel hypothetical protein (YP_498675.1) from Staphylococcus aureus unravels the protein of tryptophan synthase beta superfamily (Try-synth-beta_ II).Journal, genetic engineering & biotechnology · 2023Article
- Functional characterization of hypothetical proteins from Monkeypox virus.Journal, genetic engineering & biotechnology · 2023Article
- Human adenovirus DNA polymerase is evolutionarily and functionally associated with human telomerase reverse transcriptase based onFrontiers in bioinformatics · 2023Article
- Hypothetical protein predicted to be tumor suppressor: a protein functional analysis.Genomics & informatics · 2022Article
- Integrated bioinformatics based subtractive genomics approach to decipher the therapeutic function of hypothetical proteins from Salmonella typhi XDR H-58 strain.Biotechnology letters · 2022Article
- Characterization of Mercury-Resistant Rhizobacteria for Plant Growth Promotion: An In Vitro and In Silico Approach.Current microbiology · 2021Article
- Manual Annotation Studio (MAS): a collaborative platform for manual functional annotation of viral and microbial genomes.BMC genomics · 2021Article
- A novel cystatin derived from Trichinella spiralis suppresses macrophage-mediated inflammatory responses.PLoS neglected tropical diseases · 2020Article
- An Educational Bioinformatics Project to Improve Genome Annotation.Frontiers in microbiology · 2020Article
- Article
- Current Status and Potential Applications of Underexplored Prokaryotes.Microorganisms · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHuman adenoviruses are small double stranded DNA viruses that provoke vast array of human diseases. Next generation sequencing techniques increase genomic data of HAdV rapidly, which increase their serotypes. The complete genome sequence of human adenovirus shows that it contains large amount of proteins with unknown cellular or biochemical function, known as hypothetical proteins. Hence, it is indispensable to functionally and structurally annotate these proteins to get better understanding of the novel drug targets. The purpose was the characterization of 38 randomly retrieved hypothetical proteins through determination of their physiochemical properties, subcellular localization, function, structure and ligand binding sites using various sequence and structure based bioinformatics tools.
resultsFunction of six hypothetical proteins P03269, P03261, P03263, Q83127, Q1L4D7 and I6LEV1 were predicted confidently and then used further for structure analysis. We found that these proteins may act as DNA terminal protein, DNA polymerase, DNA binding protein, adenovirus E3 region protein CR1 and adenoviral protein L1. Functional and structural annotation leading to detection of binding sites by means of docking analysis can indicate potential target for therapeutics to defeat adenoviral infection.
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Registered trials
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