ArticleBMC pediatrics2017
Epidemiology and outcomes of children with renal failure in the pediatric ward of a tertiary hospital in Cameroon.
Article in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The incidence of and risk factors for late presentation of childhood chronic kidney disease: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Incidence and recognition of acute kidney injury in a semirural pediatric ward in Cameroon: a single-center prospective study.BMC nephrology · 2026Observational
- Chronic kidney disease (stages 3-5) in children at Chris Hani Baragwanath Academic Hospital, 2000-2019.BMC nephrology · 2026Article
- The relevance of acute kidney injury in dehydrated children.Frontiers in pediatrics · 2025Review
- Article
- Burden of Paediatric Kidney Diseases in a Tertiary Care Hospital in Harare, Zimbabwe.Clinical medicine insights. Pediatrics · 2023Article
- Burden and severity of deranged electrolytes and kidney function in children seen in a tertiary hospital in Kano, northern Nigeria.PloS one · 2023Article
- Pharmacokinetics of Antimicrobials in Children with Emphasis on Challenges Faced by Low and Middle Income Countries, a Clinical Review.Antibiotics (Basel, Switzerland) · 2022Review
- Epidemiology of haemodialysis outcomes.Nature reviews. Nephrology · 2022Review
- Policy in pediatric nephrology: successes, failures, and the impact on disparities.Pediatric nephrology (Berlin, Germany) · 2021Review
- Chronic kidney disease impacts health-related quality of life of children in Uganda, East Africa.Pediatric nephrology (Berlin, Germany) · 2021Article
- Challenges and Outcomes of Paediatric Dialysis in a Tertiary Referral Hospital, Northwest Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric nephrology is challenging in developing countries and data on the burden of kidney disease in children is difficult to estimate due to absence of renal registries. We aimed to describe the epidemiology and outcomes of children with renal failure in Cameroon.
methodsWe retrospectively reviewed 103 medical records of children from 0 to 17 years with renal failure admitted in the Pediatric ward of the Douala General Hospital from 2004 to 2013. Renal failure referred to either acute kidney injury (AKI) or Stage 3-5 chronic kidney disease (CKD). AKI was defined and graded using either the modified RIFLE criteria or the Pediatrics RIFLE criteria, while CKD was graded using the KDIGO criteria. Outcomes of interest were need and access to dialysis and in-hospital mortality. For patients with AKI renal recovery was evaluated at 3 months.
resultsMedian age was 84 months (1QR:15-144) with 62.1% males. Frequent clinical symptoms were asthenia, anorexia, 68.8% of participants had anuria. AKI accounted for 84.5% (n = 87) and CKD for 15.5% (n = 16). Chronic glomerulonephritis (9/16) and urologic malformations (7/16) were the causes of CKD and 81.3% were at stage 5. In the AKI subgroup, 86.2% were in stage F, with acute tubular necrosis (n = 50) and pre-renal AKI (n = 31) being the most frequent mechanisms. Sepsis, severe malaria, hypovolemia and herbal concoction were the main etiologies. Eight of 14 (57%) patients with CKD, and 27 of 40 (67.5%) with AKI who required dialysis, accessed it. In-hospital mortality was 50.7% for AKI and 50% for CKD. Of the 25 patients in the AKI group with available data at 3 months, renal recovery was complete in 22, partial in one and 2 were dialysis dependent. Factors associated to mortality were young age (p = 0.001), presence of a coma (p = 0.021), use of herbal concoction (p = 0.024) and acute pulmonary edema (p = 0.011).
conclusionRenal failure is severe and carries a high mortality in hospitalized children in Cameroon. Limited access to dialysis and lack of specialized paediatric nephrology services may explain this dismal picture.
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