ArticleThyroid : official journal of the American Thyroid Association2018
Stable Isotope Pharmacokinetic Studies Provide Insight into Effects of Age, Sex, and Weight on Levothyroxine Metabolism.
Article in Thyroid : official journal of the American Thyroid Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Factors influencing postoperative thyroid-stimulating hormone suppression therapy in low-risk papillary thyroid cancer after lobectomy.Gland surgery · 2026Article
- Developing a machine learning-based predictive model for levothyroxine dosage estimation in hypothyroid patients: a retrospective study.Frontiers in endocrinology · 2025Article
- Gender, FT4 levels, T stage, and BMI as predictors of TSH levels in thyroid cancer patients.Frontiers in endocrinology · 2025Article
- Deiodinase Type 3 Polymorphism (rs1190716) Affects Therapeutic Response to Levothyroxine.Turkish journal of pharmaceutical sciences · 2023Article
- Age-based factors modulating the required thyroxine dose to achieve thyrotropin suppression in intermediate-and high-risk papillary thyroid cancer.Frontiers in endocrinology · 2023Article
- Article
- Changes in TSH levels in athyreotic patients with differentiated thyroid cancer during levothyroxine therapy: influence on dose adjustments.Journal of endocrinological investigation · 2019Article
- Levothyroxine Dose Adjustment to Optimise Therapy Throughout a Patient's Lifetime.Advances in therapy · 2019Review
- Individualised requirements for optimum treatment of hypothyroidism: complex needs, limited options.Drugs in context · 2019Review
- Thyroxine Treatment With Softgel Capsule Formulation: Usefulness in Hypothyroid Patients Without Malabsorption.Frontiers in endocrinology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThis study sought to determine whether levothyroxine pharmacokinetics (PKs) are affected by age, weight, and sex.
methodsA PK study was performed after administration of a tracer dose of carbon-13-labeled LT4 (
resultsEight males and 33 females with a median age of 50 years (range 22-78 years) and median weight of 65.9 kg (range 50-150 kg) were enrolled in the study. The median
conclusionPrior studies suggest that patient age affects levothyroxine dose requirement. This study did not identify an effect of age and suggests that age-related changes in levothyroxine pharmacokinetics may be mediated by age-related weight differences. Physicians should consider a patient's weight, rather than age, for estimating levothyroxine dosage requirement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.