Evidence map›Paper›PMID 29212279›Full record

ArticleOncotarget2017

Association between depression and brain tumor: a systematic review and meta-analysis.

Jing Huang, Chao Zeng, Juxiong Xiao, Danwei Zhao, Hui Tang, Haishan Wu, Jindong Chen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07628647 (Pilot Study of the Living Well With Brain Cancer Intervention), which is not on this map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07628647 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Study of the Living Well With Brain Cancer Intervention

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2027Enrolled64ConditionsBrain CancerArmsGroup Self-Management Sessions, Educational Materials Only
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  8. Bipolar disorder in oncology: Considerations for the psychiatrist.Journal of mood and anxiety disorders · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing HuangDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chao ZengDepartment of Thoracic Surgery, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Juxiong XiaoDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Danwei ZhaoXiangya Medical School, Central South University, Changsha, Hunan, China.
Hui TangDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Haishan WuDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jindong ChenDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with brain tumor are in risk of depression or depressive symptoms, but the estimated prevalence varies between studies. The aim of this study is to get a proper summarized estimate of depression prevalence in brain tumor patients.

methodsLiterature search on Pubmed, PsycINFO, and Cochrane library from January 1981 through October 2016. The prevalence of depression or depressive symptoms in brain tumor patients was estimated by screening scales and analyzed using stratified meta-analysis and subgroup analysis. The prevalence of depression level or symptoms during the follow-up periods was detected by secondary analysis.

resultsAmong the 37 studies included in this meta-analysis, 25 used a cross-sectional design and 12 used longitudinal study. The pooled prevalence was 21.7% (971/4518 individuals, 95 % confidence interval (CI) 18.2%-25.2%) for overall sample. Lower prevalence was detected in studies with sample size ≥100 than <100, lower grade tumor than high grade tumor, studies using clinician-rated depression scales than self-rated or non-depression-specific ones, and in patients from UK, Germany and Italy than USA. After analyzing 6 longitudinal studies, prevalence of depression remained no change in the follow-up periods. No significant differences were observed between study designs and tumor types.

conclusionsThe estimated prevalence of depression or depressive symptoms among brain tumor patients was 21.7%, affected by depression assessment type, sample size, tumor grade and country. Diagnosis and treatment of co-morbid depression in brain tumor patients need to be addressed in future studies for better life quality and oncology management.

Indexed as

brain tumordepressiondepressive disorderdepressive symptomsmeta-analysis

Identifiers

PMID29212279
PMCPMC5706925

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.