Evidence map›Paper›PMID 29212271›Full record

ArticleOncotarget2017

Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage.

Cheng-Di Chiu, Nai-Wei Yao, Jeng-Hung Guo, Chiung-Chyi Shen, Hsu-Tung Lee, You-Pen Chiu, Hui-Ru Ji, Xianxiu Chen, Chun-Chung Chen, Chen Chang

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Toll like receptor 4 (TLR4) in neuroinflammation: From acute hemorrhagic stroke to chronic neurodegeneration.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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  4. CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Cheng-Di ChiuSchool of Medicine, China Medical University, Taichung, Taiwan.
Nai-Wei YaoSchool of Medicine, China Medical University, Taichung, Taiwan.
Jeng-Hung GuoDepartment of Neurosurgery, China Medical University Hospital, Taichung, Taiwan.
Chiung-Chyi ShenDepartment of Minimally Invasive Skull Base Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.
Hsu-Tung LeeDepartment of Neurosurgical Oncology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.
You-Pen ChiuSchool of Medicine, China Medical University, Taichung, Taiwan.
Hui-Ru JiGraduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.
Xianxiu ChenSchool of Medicine, China Medical University, Taichung, Taiwan.
Chun-Chung ChenSchool of Medicine, China Medical University, Taichung, Taiwan.
Chen ChangInstitute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan.
China Medical University · TWChina Medical University Hospital · TWTaichung Veterans General Hospital · TWInstitute of Biomedical Sciences, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological deterioration of intracerebral hemorrhage (ICH) mostly occurs within the first 24 hours. Together with the microglia/macrophages (MMΦ), astrocytes are important cell population responsible for many brain injuries but rarely being highlighted in acute stage of ICH. In present study, we induced rats ICH either by collagenase or autologous blood injection. Experimental groups were classified as vehicle or Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3) treatment group (

Indexed as

acute strokeastrocyteblood–brain barrierintracerebral hemorrhageMRI

Identifiers

PMID29212271
PMCPMC5706917
OpenAlexW2767002911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.