Evidence map›Paper›PMID 29212135›Full record

ArticleDepression and anxiety2018

What is the effect on comorbid personality disorder of brief panic-focused psychotherapy in patients with panic disorder?

John R Keefe, Barbara L Milrod, Robert Gallop, Jacques P Barber, Dianne L Chambless

Open access · greenAbstract read
In one paragraph

Article in Depression and anxiety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Psychological interventions for antisocial personality disorder.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Psychological therapies for people with borderline personality disorder.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Trial
  4. Trial
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

John R KeefeDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7250-8960
Barbara L MilrodDepartment of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
Robert GallopDepartment of Mathematics, West Chester University, West Chester, PA, USA.
Jacques P BarberDerner Institute of Advanced Psychological Studies, Adelphi University, Garden City, NY, USA.
Dianne L ChamblessDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USAdelphi University · USCornell University · USWest Chester University · US

Funding

Dynamic Therapy Vs. CBT for Panic DisorderR01MH070918 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MILROD, BARBARA L · 2006 to 2012
$2.3M
Dynamic Therapy Vs. CBT for Panic DisorderR01MH070664 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI CHAMBLESS, DIANNE L. · 2006 to 2010
$2.3M
NIMH NIH HHS R01 MH070664NIMH NIH HHS R01 MH070918
6 · The paper itself

Abstract

backgroundNo studies of psychotherapies for panic disorder (PD) have examined effects on comorbid personality disorders (PersD), yet half such patients have a PersD.

methodsIn a randomized trial for PD with and without agoraphobia comparing Cognitive-Behavioral Therapy (CBT) and Panic-Focused Psychodynamic Psychotherapy (PFPP), PersD was assessed pre-to-post treatment with the Structured Clinical Interview for the Diagnosis of Axis-II Disorders (SCID-II). For patients completing therapy (n = 118, 54 with PersD), covariance between panic and SCID-II criteria improvements was analyzed. SCID-II diagnostic remission and recovery were evaluated. Comparative efficacy of PFPP versus CBT for improving PersD was analyzed both for the average patient, and as a function of PersD severity.

results37 and 17% of PersD patients experienced diagnostic PersD remission and recovery, respectively. Larger reductions in PersD were related to more panic improvement, with a modest effect size (r = 0.28). Although there was no difference between treatments in their ability to improve PersD for the average patient (d = 0.01), patients meeting more PersD criteria did better in PFPP compared to CBT (P = .007), with PFPP being significantly superior at 11 criteria and above (d = 0.66; 3 more criteria lost).

conclusionsPersD presenting in the context of primary PD rarely resolves during psychotherapies focused on PD, and change in PersD only moderately tracks panic improvements, indicating non-overlap of the constructs. Patients receiving panic-focused psychotherapies may require additional treatment for their PersD. PFPP may be superior at improving severe PersD, but replication of this finding is required.

Indexed as

Outcome Assessment, Health CareAdolescentAdultAgedAgoraphobiaCognitive Behavioral TherapyComorbidityFemaleHumansMaleMiddle AgedPanic DisorderPersonality DisordersPsychotherapy, PsychodynamicYoung AdultCBTclinical trialsempirically supported treatmentspanic attacks/agoraphobiapersonality disorderpsychoanalytic/psychodynamic

Identifiers

PMID29212135
PMCPMC5842115
OpenAlexW2771750262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.