Evidence map›Paper›PMID 29212033›Full record

ArticleCell reports2017

Enhancer SINEs Link Pol III to Pol II Transcription in Neurons.

Cristina Policarpi, Luca Crepaldi, Emily Brookes, Justyna Nitarska, Sarah M French, Alessandro Coatti, Antonella Riccio

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cristina PolicarpiMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Luca CrepaldiMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Emily BrookesMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Justyna NitarskaMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Sarah M FrenchMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Alessandro CoattiMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Antonella RiccioMRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK. Electronic address: a.riccio@ucl.ac.uk.
MRC Laboratory for Molecular Cell Biology · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Spatiotemporal regulation of gene expression depends on the cooperation of multiple mechanisms, including the functional interaction of promoters with distally located enhancers. Here, we show that, in cortical neurons, a subset of short interspersed nuclear elements (SINEs) located in the proximity of activity-regulated genes bears features of enhancers. Enhancer SINEs (eSINEs) recruit the Pol III cofactor complex TFIIIC in a stimulus-dependent manner and are transcribed by Pol III in response to neuronal depolarization. Characterization of an eSINE located in proximity to the Fos gene (Fos

Indexed as

AnimalsMiceNeuronsPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidRNA Polymerase IIRNA Polymerase IIIShort Interspersed Nucleotide ElementsTranscription Factors, TFIIITranscription Factor TFIIICTranscription, GeneticRNA Polymerase IIRNA Polymerase IIITranscription Factors, TFIIITranscription Factor TFIIICenhancersepigeneticsneuronal activityneuronal developmentneuroscienceSINEstranscription

Identifiers

PMID29212033
PMCPMC5732322
OpenAlexW2775789962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.