Evidence map›Paper›PMID 29212025›Full record

ArticleCell reports2017

Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.

Sara Badodi, Adrian Dubuc, Xinyu Zhang, Gabriel Rosser, Mariane Da Cunha Jaeger, Michelle M Kameda-Smith, Anca Sorana Morrissy, Paul Guilhamon, Philipp Suetterlin, Xiao-Nan Li and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 38 citations in OpenAlex.

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  18. Harnessing brain development to understand brain tumours.Development (Cambridge, England) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Sara BadodiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Adrian DubucProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, ON M5G 1L7, Canada.
Xinyu ZhangBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Gabriel RosserBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Mariane Da Cunha JaegerBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Michelle M Kameda-SmithPediatric Neurosurgery, Department of Surgery, McMaster Children's Hospital and McMaster Stem Cell & Cancer Research Institute, MDCL 5027, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.
Anca Sorana MorrissyProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, ON M5G 1L7, Canada.
Paul GuilhamonPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada.
Philipp SuetterlinDepartment of Craniofacial Development and Stem Cell Biology, King's College London, Floor 27, Guy's Hospital Tower Wing, London SE1 9RT, UK.
Xiao-Nan LiTexas Children's Cancer Centre, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin Street, MC-3-3320, Houston, TX 77479, USA.
Loredana GuglielmiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Ashirwad MerveBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Hamza FarooqProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, ON M5G 1L7, Canada.
Mathieu LupienPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada.
Sheila K SinghPediatric Neurosurgery, Department of Surgery, McMaster Children's Hospital and McMaster Stem Cell & Cancer Research Institute, MDCL 5027, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.
M Albert BassonDepartment of Craniofacial Development and Stem Cell Biology, King's College London, Floor 27, Guy's Hospital Tower Wing, London SE1 9RT, UK.
Michael D TaylorProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, ON M5G 1L7, Canada.
Silvia MarinoBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK. Electronic address: s.marino@qmul.ac.uk.
Queen Mary University of London · GBHospital for Sick Children · CAMcMaster Children's Hospital · CAGuy's Hospital · GBKing's College London · GBTexas Children's Hospital · USUniversity Health Network · CAUniversity of Toronto · CA

Funding

Medical Research Council G0902001Medical Research Council MR/N000528/1Medical Research Council MR/N026063/1
6 · The paper itself

Abstract

We describe molecular convergence between BMI1 and CHD7 in the initiation of medulloblastoma. Identified in a functional genomic screen in mouse models, a BMI1

Indexed as

AnimalsBlotting, WesternCell ProliferationChromatinDNA-Binding ProteinsExtracellular Signal-Regulated MAP KinasesFemaleMaleMedulloblastomaMicePolycomb Repressive Complex 1Protein Tyrosine PhosphatasesProto-Oncogene ProteinsSignal TransductionBmi1 protein, mouseChd7 protein, mouseChromatinDNA-Binding ProteinsDusp4 protein, mouseExtracellular Signal-Regulated MAP KinasesPolycomb Repressive Complex 1Protein Tyrosine PhosphatasesProto-Oncogene ProteinsBMI1CHD7chromatinDUSP4epigeneticsERKmedulloblastomamouse modelsPcG genes

Identifiers

PMID29212025
PMCPMC5732319
OpenAlexW2773618384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.