ArticleCell reports2017
Alpha2delta-1 in SF1
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Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability.Molecular metabolism · 2025Article
- α2δ-1-Linked NMDA and AMPA Receptors in Neuropathic Pain and Gabapentinoid Action.Journal of neurochemistry · 2025Review
- Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms.International journal of molecular sciences · 2024Review
- α2δ1-mediated maladaptive sensory plasticity disrupts adipose tissue homeostasis following spinal cord injury.Cell reports. Medicine · 2024Article
- Calcineurin regulates synaptic CaThe Journal of physiology · 2024Article
- TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner.Journal of lipid research · 2023Article
- The α2δ-1-NMDA receptor complex and its potential as a therapeutic target for ischemic stroke.Frontiers in neurology · 2023Review
- Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity.Science advances · 2022Article
- Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis.Nature metabolism · 2022Article
- Role of High Voltage-Gated CaCells · 2021Review
- Rap1 in the VMH regulates glucose homeostasis.JCI insight · 2021Article
- New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes.International journal of molecular sciences · 2021Review
- Electroconvulsive seizures lead to lipolytic-induced gene expression changes in mediobasal hypothalamus and decreased white adipose tissue mass.Neuropsychopharmacology reports · 2021Article
- Essential and sex-specific effects of mGluR5 in ventromedial hypothalamus regulating estrogen signaling and glucose balance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity.Current opinion in neurobiology · 2020Review
- Sex-specific Effects of α2δ-1 in the Ventromedial Hypothalamus of Female Mice Controlling Glucose and Lipid Balance.Endocrinology · 2020Article
- Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Emergent decision-making behaviour and rhythm generation in a computational model of the ventromedial nucleus of the hypothalamus.PLoS computational biology · 2019Article
- α2δ-1-Bound N-Methyl-D-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents.Anesthesiology · 2019Article
- Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain.Journal of neurochemistry · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Jennifer A FelstedGraduate Program in Biochemical and Molecular Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA.
Cheng-Hao ChienDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Dongqing WangMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Micaella PanessitiGraduate Program in Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Dominique AmerosoGraduate Program in Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Andrew GreenbergGraduate Program in Biochemical and Molecular Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA; USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Guoping FengMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Dong KongDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA; Graduate Program in Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Maribel RiosDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA; Graduate Program in Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: maribel.rios@tufts.edu.
Tufts University · USMcGovern Institute for Brain Research · US
Funding
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MTUSM/T-NEMC CENTER FOR NEUROSCIENCE RESEARCH - Imaging CoreP30NS047243 · NINDS · TUFTS UNIVERSITY BOSTON · PI JACKSON, F ROB · 2003 to 2017
$10.0MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MBDNF and TrkB-Containing Neuronal Circuits Mediating Energy BalanceR01DK073311 · NIDDK · TUFTS UNIVERSITY BOSTON · PI RIOS, MARIBEL · 2007 to 2014
$2.8MResearch Training Program in Nutrition, Obesity and Metabolic DisordersT32DK062032 · NIDDK · TUFTS UNIVERSITY BOSTON · PI GREENBERG, ANDREW S · 2002 to 2016
$2.6MA Neural Circuit of Energy Expenditure Preventing ObesityR01DK108797 · NIDDK · TUFTS UNIVERSITY BOSTON · PI KONG, DONG · 2016 to 2020
$2.3MSynapse Neurobiology Training ProgramT32NS061764 · NINDS · TUFTS UNIVERSITY BOSTON · PI BIEDERER, THOMAS · 2009 to 2019
$1.7MGenetic and Optic Dissection of AMPK Dynamics in NeurotransmissionR21NS097922 · NINDS · TUFTS UNIVERSITY BOSTON · PI KONG, DONG · 2016 to 2017
$454kNIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK073311NIDDK NIH HHS R01 DK108797NIDDK NIH HHS T32 DK062032NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637NINDS NIH HHS P30 NS047243NINDS NIH HHS R21 NS097922NINDS NIH HHS T32 NS061764
Abstract
The central mechanisms controlling glucose and lipid homeostasis are inadequately understood. We show that α2δ-1 is an essential regulator of glucose and lipid balance, acting in steroidogenic factor-1 (SF1) neurons of the ventromedial hypothalamus (VMH). These effects are body weight independent and involve regulation of SF1
Indexed as
AnimalsBlotting, WesternCalcium Channels, L-TypeElectrophysiologyEnergy MetabolismFluorescent Antibody TechniqueGlucoseHomeostasisLipidsMiceNeuronsRNA Splicing FactorsVentral Thalamic NucleiCalcium Channels, L-TypeGlucoseLipidsRNA Splicing FactorsSf1 protein, mousediabetesexcitabilityglucosehypothalamuslipidnorepinephrineserotoninSF1VMH
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.