Evidence map›Paper›PMID 29212016›Full record

ArticleCell reports2017

Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.

Aditi Deshpande, Smita Yadav, Dang Q Dao, Zhi-Yong Wu, Kenton C Hokanson, Michelle K Cahill, Arun P Wiita, Yuh-Nung Jan, Erik M Ullian, Lauren A Weiss

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 166 citations in OpenAlex.

  1. Review
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  8. Frontiers in molecular neuroscience · 2026
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  14. Cell villages and Dirichlet modeling map human cell fitness genetics.bioRxiv : the preprint server for biology · 2025
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  19. A Hypothesis: Metabolic Contributions to 16p11.2 Deletion Syndrome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Aditi DeshpandeDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, 94143, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Smita YadavHoward Hughes Medical Institute , University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology , University of California, San Francisco, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics , University of California, San Francisco, San Francisco, CA 94158, USA.
Dang Q DaoDepartment of Ophthalmology, University of California, San Francisco, CA 94143, USA.
Zhi-Yong WuDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, 94143, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Kenton C HokansonDepartment of Ophthalmology, University of California, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Michelle K CahillNeuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Arun P WiitaDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA.
Yuh-Nung JanHoward Hughes Medical Institute , University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology , University of California, San Francisco, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics , University of California, San Francisco, San Francisco, CA 94158, USA.
Erik M UllianDepartment of Ophthalmology, University of California, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Lauren A WeissDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, 94143, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: lauren.weiss@ucsf.edu.
University of California, San Francisco · USHoward Hughes Medical Institute · US

Funding

Training Program for the Visual SciencesT32EY007120 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COPENHAGEN, DAVID RICHARD · 1990 to 2015
$2.9M
Dissecting Epistasis and Pleiotropy in Autism towards Personalized MedicineDP2OD007449 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISS, LAUREN ANNE · 2010 to 2014
$2.4M
Role of Autism Susceptibility Gene, TAOK2 kinase, and its novel substrates in SynaptogenesisR00MH108648 · NIMH · UNIVERSITY OF WASHINGTON · PI YADAV, SMITA · 2018 to 2020
$745k
Epigenetic loss of heterozygosity in a recurrent neurodevelopmental CNV regionR21MH105745 · NIMH · DANA-FARBER CANCER INST · PI GIMELBRANT, ALEXANDER, WEISS, LAUREN ANNE · 2014 to 2015
$456k
Role of Autism Susceptibility Gene, TAOK2 kinase, and its novel substrates in SynaptogenesisK99MH108648 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YADAV, SMITA · 2015 to 2016
$242k
NEI NIH HHS T32 EY007120NIH HHS DP2 OD007449NIMH NIH HHS K99 MH108648NIMH NIH HHS R00 MH108648NIMH NIH HHS R21 MH105745
6 · The paper itself

Abstract

A deletion or duplication in the 16p11.2 region is associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In addition to clinical characteristics, carriers of the 16p11.2 copy-number variant (CNV) manifest opposing neuroanatomical phenotypes-e.g., macrocephaly in deletion carriers (16pdel) and microcephaly in duplication carriers (16pdup). Using fibroblasts obtained from 16pdel and 16pdup carriers, we generated induced pluripotent stem cells (iPSCs) and differentiated them into neurons to identify causal cellular mechanisms underlying neurobiological phenotypes. Our study revealed increased soma size and dendrite length in 16pdel neurons and reduced neuronal size and dendrite length in 16pdup neurons. The functional properties of iPSC-derived neurons corroborated aspects of these contrasting morphological differences that may underlie brain size. Interestingly, both 16pdel and 16pdup neurons displayed reduced synaptic density, suggesting that distinct mechanisms may underlie brain size and neuronal connectivity at this locus.

Indexed as

Autism Spectrum DisorderAutistic DisorderCell DifferentiationChromosome DeletionChromosome DuplicationChromosomes, Human, Pair 16DNA Copy Number VariationsHumansInduced Pluripotent Stem CellsMegalencephalyMicrocephalyModels, GeneticNeurons16p11.2 CNVautismdeletionduplicationiPSCmacrocephalymicrocephalyneurodevelopmental disordersneurons

Identifiers

PMID29212016
PMCPMC5730067
OpenAlexW2775613815

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.