ArticleCell reports2017
Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice.Frontiers in molecular neuroscience · 2025Article
- Long noncoding RNAs heat shock RNA omega nucleates TBPH and promotes intestinal stem cell differentiation upon heat shock.iScience · 2024Article
- Growth-suppressor microRNAs mediate synaptic overgrowth and behavioral deficits in Fragile X mental retardation protein deficiency.iScience · 2024Article
- PGC-1α integrates insulin signaling with mitochondrial physiology and behavior in a Drosophila model of Fragile X Syndrome.npj metabolic health and disease · 2024Article
- Age-related ceRNA networks in adultFrontiers in genetics · 2023Article
- Review
- The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance.Genetics · 2022Article
- Imp interacts with Lin28 to regulate adult stem cell proliferation in the Drosophila intestine.PLoS genetics · 2022Article
- Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity.Current biology : CB · 2022Article
- Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome.Frontiers in cell and developmental biology · 2022Review
- A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- I-KCKT allows dissection-free RNA profiling of adultDevelopment (Cambridge, England) · 2021Article
- Tissue Adaptation to Environmental Cues by Symmetric and Asymmetric Division Modes of Intestinal Stem Cells.International journal of molecular sciences · 2020Review
- Ageing, metabolism and the intestine.EMBO reports · 2020Review
- Canonical nucleators are dispensable for stress granule assembly inJournal of cell science · 2020Article
- Lar maintains the homeostasis of the hematopoietic organ inDevelopment (Cambridge, England) · 2019Article
- Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism duringDevelopment (Cambridge, England) · 2019Article
- Generating and working with Drosophila cell cultures: Current challenges and opportunities.Wiley interdisciplinary reviews. Developmental biology · 2019Review
- The translational regulator FMRP controls lipid and glucose metabolism in mice and humans.Molecular metabolism · 2019Article
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain poorly defined. We report that the RNA-binding protein fragile X mental retardation protein (FMRP) limits the symmetric division, and resulting expansion, of the stem cell population during adaptive intestinal growth in Drosophila. The elevated insulin sensitivity that FMRP-deficient progenitor cells display contributes to their accelerated expansion, which is suppressed by the depletion of insulin-signaling components. This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR). This study identifies the stem cell-based mechanism by which FMRP controls tissue adaptation, and it raises the possibility that defective adaptive growth underlies the accelerated growth, gastrointestinal, and other symptoms that affect fragile X syndrome patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.