Evidence map›Paper›PMID 29212002›Full record

ArticleBiophysical journal2017

Going with the Flow: Water Flux and Cell Shape during Cytokinesis.

Yizeng Li, Lijuan He, Nicolas A P Gonzalez, Jenna Graham, Charles Wolgemuth, Denis Wirtz, Sean X Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Extracellular Hydraulic Resistance Enhances Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. On the energy efficiency of cell migration in diverse physical environments.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yizeng LiDepartments of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland.
Lijuan HeChemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland.
Nicolas A P GonzalezChemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland.
Jenna GrahamChemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland.
Charles WolgemuthDepartment of Physics, University of Arizona, Tucson, Arizona.
Denis WirtzChemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland; Institute of NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland.
Sean X SunDepartments of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland; Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland; Institute of NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland. Electronic address: ssun@jhu.edu.

Funding

The Role of Osmotic Engine in Confined MigrationR01GM114675 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, SUN, SEAN X · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM114675
6 · The paper itself

Abstract

Cell shape changes during cytokinesis in eukaryotic cells have been attributed to contractile forces from the actomyosin ring and the actomyosin cortex. Here we propose an additional mechanism where active pumping of ions and water at the cell poles and the division furrow can also achieve the same type of shape change during cytokinesis without myosin contraction. We develop a general mathematical model to examine shape changes in a permeable object subject to boundary fluxes. We find that hydrodynamic flows in the cytoplasm and the relative drag between the cytoskeleton network phase and the water phase also play a role in determining the cell shape during cytokinesis. Forces from the actomyosin contractile ring and cortex do contribute to the cell shape, and can work together with water permeation to facilitate cytokinesis. To influence water flow, we osmotically shock the cell during cell division, and find that the cell can actively adapt to osmotic changes and complete division. Depolymerizing the actin cytoskeleton during cytokinesis also does not affect the contraction speed. We also explore the role of membrane ion channels and pumps in setting up the spatially varying water flux.

Indexed as

Cell ShapeCytokinesisModels, BiologicalMovementActomyosinCell DivisionDNA ReplicationOsmotic PressurePermeabilityWaterActomyosinWater

Identifiers

PMID29212002
PMCPMC5738528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.