Evidence map›Paper›PMID 29211921›Full record

ArticleMuscle & nerve2018

Infections and the relationship to treatment in neuromuscular autoimmunity.

Devin E Prior, Emily Nurre, Stephanie L Roller, David Kline, Ramit Panara, Amro M Stino, John A Davis, Miriam L Freimer, W David Arnold

Abstract read
In one paragraph

Article in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Pneumonia in myasthenia gravis: Microbial etiology and clinical management.Frontiers in cellular and infection microbiology · 2022
    Article
  10. Adverse Side Effects Associated with Corticosteroid Therapy: A Study in 39 Patients with Generalized Myasthenia Gravis.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Article
  11. Neurology. Clinical practice · 2021
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Devin E PriorDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Emily NurreDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Stephanie L RollerDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
David KlineCenter for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
Ramit PanaraDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Amro M StinoDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0002-7793-6662
John A DavisDepartment of Infectious Disease, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Miriam L FreimerDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
W David ArnoldDepartment of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
The Ohio State University Wexner Medical Center · USThe Ohio State University · US

Funding

Rehabilitation Medicine Scientist Training (RMST) ProgramK12HD001097 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONINGER, MICHAEL L. · 1995 to 2016
$14.1M
NICHD NIH HHS K12 HD001097
6 · The paper itself

Abstract

introductionThis study aimed to identify infections in patients with myasthenia gravis, dermatomyositis, and chronic inflammatory demyelinating polyradiculoneuropathy, and to investigate the relationship between infection and immunomodulation.

methodsA retrospective chart review examined 631 patients with myasthenia gravis (n = 358), chronic inflammatory demyelinating polyradiculoneuropathy (n = 124), and dermatomyositis (n = 149) patients over a 10-year time period.

resultsInfection rates were similar at approximately 19% in all 3 diseases. Of the infections in which a causative organism was identified, pneumonia, sepsis, and opportunistic infections were the leading diagnoses. A multivariate model demonstrated a significant association between infection and an increased dose of plasma exchange, mycophenolate mofetil, and corticosteroid therapy. DISCUSSION: There are few large studies investigating rates of infections in patients with autoimmune neuromuscular disorders and the relationship to immunomodulation. This study not only demonstrates the remarkably similar infection rates across the 3 diseases studied, but also shows their relationship to commonly used immunotherapies. Muscle Nerve 57: 927-931, 2018.

Indexed as

Adrenal Cortex HormonesAdultAgedAged, 80 and overAutoimmunityComorbidityDermatomyositisFemaleHumansImmunosuppressive AgentsIncidenceInfectionsMaleMiddle AgedMyasthenia GravisPlasmapheresisAdrenal Cortex HormonesImmunosuppressive Agentschronic inflammatory demyelinating polyradiculoneuropathydermatomyositisimmunosuppressioninfectionmyasthenia gravis

Identifiers

PMID29211921
PMCPMC5951723
OpenAlexW2772170357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.