ArticleThe Journal of infectious diseases2018
Association Between Sporadic Legionellosis and River Systems in Connecticut.
Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Sodium levels and grazing pressure shape natural communities of the intracellular pathogen Legionella.Microbiome · 2023Article
- Legionellosis on the rise: A scoping review of sporadic, community-acquired incidence in the United States.Epidemiology and infection · 2023Article
- The effect of seasonal and extreme floods on hospitalizations for Legionnaires' disease in the United States, 2000-2011.BMC infectious diseases · 2022Article
- Association of Natural Waterways andJournal of patient-centered research and reviews · 2022Article
- Provincial trends in Legionnaires' disease are not explained by population structure in Denmark, 2015 to 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Article
- Cytotoxicity, Intracellular Replication, and Contact-Dependent Pore Formation of Genotyped EnvironmentalPathogens (Basel, Switzerland) · 2021Article
- Effects of climate changes and road exposure on the rapidly rising legionellosis incidence rates in the United States.PloS one · 2021Article
- Article
- Epidemiologic Survey of Legionella Urine Antigen Testing Within a Large Wisconsin-Based Health Care System.Journal of patient-centered research and reviews · 2020Article
- Solar and Climate Effects Explain the Wide Variation in Legionellosis Incidence Rates in the United States.Applied and environmental microbiology · 2019Article
- Identifying aerosolized cyanobacteria in the human respiratory tract: A proposed mechanism for cyanotoxin-associated diseases.The Science of the total environment · 2018Article
- Differences in Virulence BetweenFrontiers in cellular and infection microbiology · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Background: There has been a dramatic increase in the incidence of sporadic legionnaires' disease in Connecticut since 1999, but the exact reasons for this are unknown. Therefore, there is a growing need to understand the drivers of legionnaires' disease in the community. In this study, we explored the relationship between the natural environment and the spatial and temporal distribution of legionellosis cases in Connecticut. Methods: We used spatial models and time series methods to evaluate factors associated with the increase and clustering of legionellosis in Connecticut. Stream flow, proximity to rivers, and residence in regional watersheds were explored as novel predictors of disease, while controlling for testing intensity and correlates of urbanization. Results: In Connecticut, legionellosis incidence exhibited a strong pattern of spatial clustering. Proximity to several rivers and residence in the corresponding watersheds were associated with increased incidence of the disease. Elevated rainfall and stream flow rate were associated with increases in incidence 2 weeks later. Conclusions: We identified a novel relationship between the natural aquatic environment and the spatial distribution of sporadic cases of legionellosis. These results suggest that natural environmental reservoirs may have a greater influence on the spatial distribution of sporadic legionellosis cases than previously thought.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.