ArticleEuropean heart journal2018
Long-term mortality in patients with atrial septal defect: a nationwide cohort-study.
Article in European heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 116 citations in OpenAlex.
- Long-Term Outcomes of Atrial Septal Defect Closure in Adults Older than 50 Years.Pediatric cardiology · 2026Article
- Timing of Intervention and Long-Term Outcomes in Mild Congenital Heart Disease: A 35-Year Study From the Pediatric Cardiac Care Consortium.Circulation. Cardiovascular interventions · 2026Article
- Exploring Biomarkers in Congenital Heart Disease: A Case-Control Study of ST2 in Children with Atrial Septal Defects.International journal of molecular sciences · 2026Article
- Heart Rate Control with Landiolol Hydrochloride in Infants and Neonates During Cardiac Surgery.Pediatric cardiology · 2026Article
- Percutaneous Transcatheter Closure of Multiple Ostium Secundum Atrial Septal Defects: A Case Report.Cureus · 2026Article
- Physical fitness in adults with isolated secundum atrial septal defects.International journal of cardiology. Congenital heart disease · 2025Article
- Atrial Septal Defect and Heart Rhythm Disorders: Physiopathological Linkage and Clinical Perspectives.Biomedicines · 2025Review
- Long-term follow-up results of adult atrial septal defect population.BMC cardiovascular disorders · 2025Article
- Interatrial Communications: Prevalence and Subtypes in 12,385 Newborns-a Copenhagen Baby Heart Study.Pediatric cardiology · 2025Observational
- Treat-and-repair strategy for atrial septal defect with left ventricular systolic dysfunction: a case report of cardiac resynchronization therapy responder.European heart journal. Case reports · 2025Article
- Secundum atrial septal defect closure in adults in the UK.European heart journal. Quality of care & clinical outcomes · 2025Observational
- Cardiovascular outcomes in adult patients with atrial septal defect: a nationwide population-based study.Frontiers in cardiovascular medicine · 2025Article
- Neurohormonal activation pattern in patients with atrial septal defect.Scientific reports · 2024Article
- Congenital Heart Disease Surgery in Low-Resource Settings: Quality Improvement Is Key.JACC. Advances · 2024Article
- Associations With Adverse Postoperative Outcomes in Children Undergoing Atrial Septal Defect Closure in Lower-Resource Settings.JACC. Advances · 2024Article
- Temporal Trend in Hospitalization Among Patients With Congenital Heart Disease: A Danish Nationwide Study.Journal of the American Heart Association · 2024Article
- Electrocardiographic Characteristics in 438 Neonates with Atrial Septal Defects.Pediatric cardiology · 2024Observational
- Risk factors for isolated atrial septal defect secundum morbidity.Scientific reports · 2024Article
- A Case of Sinus Venosus Atrial Septal Defect: Physical Examination as a Diagnostic Clue.Cureus · 2024Article
- Long-term outcomes of transcatheter atrial septal defect closure: a single-center retrospective study.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: In this nationwide cohort of atrial septal defect (ASD) patients, the largest to date, we report the longest follow-up time with and without closure in childhood and adulthood compared with a general population cohort. Methods and results: Using population-based registries, we included Danish individuals born before 1994 who received an ASD diagnosis between 1959 and 2013. All diagnoses were subsequently validated (n = 2277). Using the Kaplan-Meier estimates and Cox proportional hazards regression adjusted for sex, birth year, and a modified Charlson Comorbidity Index, we compared the mortality of ASD patients with that of a birth year and sex matched general population cohort. The median follow-up from ASD diagnosis was 18.1 years (range 1-53 years). Patients with ASD had a higher mortality [adjusted hazard ratio (HR): 1.7; 95% confidence interval (CI): 1.5-1.9] compared with the general population cohort. The adjusted HR 30 days after closure was 1.4 (95% CI: 1.2-1.7), and it was 2.4 (95% CI: 2.0-2.9) for patients without closure. Conclusion: Overall, ASD patients had a higher long-term mortality than a general population cohort matched on birth year and gender. Our data indicate a lower relative mortality of those ASD patients undergoing closure than the ASD patients not undergoing closure.
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