ArticlePLoS neglected tropical diseases2017
Symptoms associated with adverse dengue fever prognoses at the time of reporting in the 2015 dengue outbreak in Taiwan.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk and predictive factors for severe dengue infection: A systematic review and meta-analysis.PloS one · 2022Pooled it
- AI-based prediction of dengue incidence using climatic, environmental, and socio-demographic factors: an ensemble random forest approach with agile system development.BMC infectious diseases · 2026Article
- Metabolomic atlas of dengue virus infection reveals distinct circulating bioactive lipid signatures.PLoS neglected tropical diseases · 2026Article
- Establishment of multiple predictive models for early identification of the dengue cases in outpatient healthcare systems.Scientific reports · 2026Article
- Risk factors associated with dengue lethality: case-control study, Joinville, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
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- Global prevalence and risk factors of fatigue and post-infectious fatigue among patients with dengue: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Risks of anxiety disorders, depressive disorders, and sleep disorders in patients with dengue fever: A nationwide, population-based cohort study.PLoS neglected tropical diseases · 2024Article
- Improving dengue fever predictions in Taiwan based on feature selection and random forests.BMC infectious diseases · 2024Article
- Article
- Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study.PLoS neglected tropical diseases · 2023Article
- Development and Utility of Practical Indicators of Critical Outcomes in Dengue Patients Presenting to Hospital: A Retrospective Cross-Sectional Study.Tropical medicine and infectious disease · 2023Article
- Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study.PLoS neglected tropical diseases · 2023Article
- Rapidly Containing the First Indigenous Outbreak of Chikungunya in Taiwan-Lessons Learned.Tropical medicine and infectious disease · 2021Article
- Cytokine Signature of Dengue Patients at Different Severity of the Disease.International journal of molecular sciences · 2021Article
- Comparing machine learning with case-control models to identify confirmed dengue cases.PLoS neglected tropical diseases · 2020Article
- Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models.EBioMedicine · 2020Article
- Article
- Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly.PLoS neglected tropical diseases · 2019Article
- Trajectories of hepatic and coagulation dysfunctions related to a rapidly fatal outcome among hospitalized patients with dengue fever in Tainan, 2015.PLoS neglected tropical diseases · 2019Article
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8 authors.
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Abstract
backgroundTainan experienced the most severe dengue epidemic in Taiwan in 2015. This study investigates the association between the signs and symptoms at the time of reporting with the adverse dengue prognoses.
methodsA descriptive study was conducted using secondary data from the Dengue Disease Reporting System in Tainan, Taiwan, between January 1 and December 31, 2015. A multivariate stepwise logistic regression was used to identify the risk factors for the adverse prognoses: ICU admissions and mortality.
resultsThere were 22,777 laboratory-confirmed reported cases (mean age 45.6 ± 21.2 years), of which 3.7% were admitted to intensive care units (ICU), and 0.8% were fatal. The most common symptoms were fever (92.8%), myalgia (26.6%), and headache (22.4%). The prevalence of respiratory distress, altered consciousness, shock, bleeding, and thrombocytopenia increased with age. The multivariate analysis indicated that being in 65-89 years old age group [Adjusted Odds Ratio (aOR):4.95], or the 90 years old and above age group (aOR: 9.06), and presenting with shock (aOR: 8.90) and respiratory distress (aOR: 5.31) were significantly associated with the risk of ICU admission. While old age (aOR: 1.11), respiratory distress (aOR: 9.66), altered consciousness (aOR: 7.06), and thrombocytopenia (aOR: 2.55) were significantly associated with the risk of mortality.
conclusionsDengue patients older than 65 and those with severe and non-specific signs and symptoms at the time of reporting were at a higher risk of ICU admission and mortality. First-line healthcare providers need to be aware of the varied presentations between the different age groups to allow early diagnosis and in-time management, which would prevent ICU admissions and fatalities in dengue patients.
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