Evidence map›Paper›PMID 29211740›Full record

SynthesisPloS one2017

A systematic review and meta-analysis of comprehensive interventions for pre-school children with autism spectrum disorder (ASD).

Yoshiyuki Tachibana, Celine Miyazaki, Erika Ota, Rintaro Mori, Yeonhee Hwang, Eriko Kobayashi, Akiko Terasaka, Julian Tang, Yoko Kamio

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  18. A cross-sectional study on extensive gaming in adolescents.Journal of public health research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoshiyuki TachibanaDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Centre for Child Health and Development, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9614-7477
Celine MiyazakiDepartment of Health Policy, National Research Institute for Child Health and Development, Tokyo, Japan.
Erika OtaDepartment of Health Policy, National Research Institute for Child Health and Development, Tokyo, Japan.
Rintaro MoriDepartment of Health Policy, National Research Institute for Child Health and Development, Tokyo, Japan.
Yeonhee HwangDepartment of Education, Tohoku Fukushi University, Sendai, Japan.
Eriko KobayashiDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Centre for Child Health and Development, Tokyo, Japan.
Akiko TerasakaDepartment of Educational Collaboration, Osaka Kyoiku University, Osaka, Japan.
Julian TangDepartment of Education for Clinical Research, National Centre for Child Health and Development, Tokyo, Japan.
Yoko KamioDepartment of Child and Adolescent Mental Health, National Center for Neurology and Psychiatry, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere has an increasing number of published trials on psychosocial intervention programmes for pre-school children with autism spectrum disorder (ASD). To achieve better quality of unbiased evidence for the effectiveness of ASD interventions, it is necessary to conduct a comprehensive review that covers studies with adequate quality standards, such as randomised controlled trials (RCTs), and different types of intervention In this study, we categorize interventions for ASD as behavioural, social-communication focused, and multimodal developmental based on Howlin's classification of early interventions for children with ASD. The aim of this study was to compare these three models and investigate the strengths and weaknesses of each type of intervention and to identify the approaches that contribute to a successful outcome for children with autism.

methodsWe performed a systematic review and meta-analysis. We included RCTs targeting children with ASD 6 years old or younger. A random effects model was used to present the effect estimate for the outcomes. This study also performed combined meta-analyses of all the three models to investigate the overall effectiveness of the intervention programmes.

results32 randomized controlled studies were found to be eligible for inclusion. The synthesized data included 594 children from 14 RCTs. There was no statistically significant difference in the effects on autism general symptoms between the social-communication-focused model and the multimodal developmental model (p = 0.83). The results suggest that there is evidence of an effect on 'reciprocity of social interaction towards others' (standard mean difference [95% confidential interval] = 0.53[0.29,0.78], p<0.01) and 'parental synchrony' (SMD = 0.99[0.70,1.29], p<0.01).

conclusionThe small number of studies included in the present study limited the ability to make inferences when comparing the three models and investigating the strengths and weaknesses of each type of intervention with respect to important outcomes. Since the outcome of 'reciprocity of social interaction towards others' could be a dependent variable that might be context-bound to interactions with the child's parent, we cannot conclude the interventions for pre-school children with ASD have significant effects on a generalized skill to engage in reciprocal interactions with others. However, the outcomes of 'reciprocity of social interaction towards others' and 'parental synchrony' may be promising targets for interventions involving pre-school children with ASD.

trial registrationProspero CRD42011001349.

Indexed as

Autism Spectrum DisorderBehavior TherapyChild, PreschoolFemaleHumansMaleRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID29211740
PMCPMC5718481

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.