Evidence map›Paper›PMID 29211286›Full record

ArticleJournal of applied oral science : revista FOB

Association of single nucleotide polymorphisms in AXIN2, BMP4, and IRF6 with Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population.

Houshang Rafighdoost, Mohammad Hashemi, Hiva Danesh, Fatemeh Bizhani, Gholamreza Bahari, Mohsen Taheri

Open access · diamondAbstract read
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In one paragraph

Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Houshang RafighdoostZahedan University of Medical Sciences, Cellular and Molecular Research Center, Zahedan, Iran.
Mohammad HashemiZahedan University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry, Zahedan, Iran.
Hiva DaneshZahedan University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry, Zahedan, Iran.
Fatemeh BizhaniZahedan University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry, Zahedan, Iran.
Gholamreza BahariZahedan University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry, Zahedan, Iran.
Mohsen TaheriGenetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Zahedan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNon-syndromic cleft lip with or without palate (NSCL/P) is a common congenital malformation worldwide, with complex etiology. It has been proposed that interaction of genes and environmental factors play a role in the predisposition to this disease. The aim of this study was to examine the association between AXIN2 (axis inhibition protein 2) rs7224837, BMP4 (bone morphogenetic protein 4) rs17563, and IRF6 (interferon regulatory factor 6) rs861019 and 2235371 polymorphisms and NSCL/P in an Iranian population. MATERIAL AND

methodsThis case-control study was carried out on 132 unrelated NSCL/P patients and 156 healthy subjects. The variants were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

resultsThe findings suggest that BMP4 rs17563 polymorphism significantly decreased the risk of NSCL/P in codominant (OR=0.36, 95%CI=0.17-0.79, p=0.012, CT vs CC and OR=0.11, 95%CI=0.01-0.88, p = 0.019, TT vs CC), dominant (OR=0.30, 95%CI=0.15-0.62, p = 0.0007, CT+TT vs CC), recessive (OR=0.12, 95%CI=0.02-0.99, p = 0.023, TT vs CC+CT), overdominant (OR=0.39, 95%CI = 0.18-0.84, p=0.021, CT vs CC+TT), and allele (OR=0.28, 95%CI=0.15-0.55, p<0.0001, T vs C) inheritance models. Our findings did not support an association between AXIN2 rs7224837 and IRF6 rs861019 polymorphism and risk/protection of NSCL/P. The IRF6 2235371 variant was not polymorphic in our population.

conclusionThe results indicate that the BMP4 rs17563 variant is likely to confer a protective effect against the occurrence of NSCL/P in a sample of the southeast Iranian population.

Indexed as

Axin ProteinBone Morphogenetic Protein 4Case-Control StudiesChildCleft LipCleft PalateFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansInterferon Regulatory FactorsIranMalePolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotideAXIN2 protein, humanAxin ProteinBone Morphogenetic Protein 4Interferon Regulatory FactorsIRF6 protein, human

Identifiers

PMID29211286
PMCPMC5701535
OpenAlexW2770350024

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.