Trial reportJournal of applied oral science : revista FOB
Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial.
Trial report in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- The Risk of Preterm Birth in Women With Periodontitis: A Systematic Review and Meta-Analysis.International journal of dental hygiene · 2026Pooled it
- Periodontitis and Platelets Status: A Systematic Review With Meta-Analysis and Trial Sequential Analysis.Journal of periodontal research · 2025Pooled it
- Cardiovascular Disease and Chronic Endodontic Infection. Is There an Association? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Do hydrogen peroxide mouthwashes have a virucidal effect? A systematic review.The Journal of hospital infection · 2020Pooled it
- Preoperative Mouthwash in Subjects with Different Periodontal Status: A Randomised Controlled Clinical Trial.Oral health & preventive dentistry · 2020Trial
- Effect of antiseptic gels in the microbiologic colonization of the suture threads after oral surgery.Scientific reports · 2020Trial
- Impact of severe periodontitis and diabetes mellitus on recurrent cardiovascular outcomes.Journal of periodontology · 2026Article
- Oral normality alterations and the impact on pneumonia, sepsis, and bloodstream infections in critically ill patients: a prospective cohort study.Critical care science · 2026Article
- A Review on the Role of Oral Bacteria in Stroke.International journal of molecular sciences · 2025Review
- Bacterial translocation signatures and subgingival microbiome in individuals with periodontitis.Clinical oral investigations · 2025Article
- Stroke Caused by Vasculitis Induced by Periodontitis-Associated Oral Bacteria after Wisdom Teeth Extraction.Brain sciences · 2024Article
- Bacteremia Prevention during Periodontal Treatment-An In Vivo Feasibility Study.Antibiotics (Basel, Switzerland) · 2023Article
- PeriodontopathogensPathogens (Basel, Switzerland) · 2023Review
- A Cross-Sectional Study to Evaluate Dental Professionals' Knowledge of Antiplaque Mouth Rinse Agents and their Application in Periodontal Practice.Journal of pharmacy & bioallied sciences · 2023Article
- Antimicrobial Efficacy of Three Different Mouthwashes on Periodontal Pathogens-AnJournal of pharmacy & bioallied sciences · 2023Article
- Short- and long term antibacterial effects of a single rinse with different mouthwashes: A randomized clinical trial.Heliyon · 2023Article
- Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2.International journal of environmental research and public health · 2022Review
- Chronic Endodontic Infections and Cardiovascular Diseases: Does the Evidence Support an Independent Association?Cureus · 2021Review
- Periodontitis and cardiovascular diseases: Consensus report.Journal of clinical periodontology · 2020Review
- Periodontitis and Cardiovascular Diseases. Consensus Report.Global heart · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSingle dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. MATERIAL AND
methodsSystemically healthy individuals with gingivitis (n=27) or periodontitis (n = 27) were randomly allocated through a sealed envelope system to: 0.12% chlorhexidine pre-procedural rinse (13 gingivitis and 13 periodontitis patients) or no rinse before dental scaling (14 gingivitis and 15 periodontitis patients). Periodontal probing depth, clinical attachment level, plaque, and gingival indices were measured and subgingival samples were collected. Blood samples were collected before dental scaling, 2 and 6 minutes after scaling. Total bacterial load and levels of P. gingivalis were determined in oral and blood samples by real-time polymerase chain reaction, while aerobic and anaerobic counts were determined by culture in blood samples. The primary outcome was the antimicrobial effect of the pre-procedural rinse. Data was compared by Mann-Whitney and Signal tests (p<0.05).
resultsIn all sampling times, polymerase chain reaction revealed higher blood bacterial levels than culture (p<0.0001), while gingivitis patients presented lower bacterial levels in blood than periodontitis patients (p<0.0001). Individuals who experienced bacteremia showed worse mean clinical attachment level (3.4 mm vs. 1.1 mm) and more subgingival bacteria (p<0.005). The pre-procedural rinse did not reduce induced bacteremia.
conclusionsBacteremia was influenced by periodontal parameters. In periodontally diseased patients, pre-procedural rinsing showed a discrete effect on bacteremia control.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.