ArticleMemorias do Instituto Oswaldo Cruz2017
Dengue serotype-specific immune response in Aedes aegypti and Aedes albopictus.
Article in Memorias do Instituto Oswaldo Cruz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Immune-related transcripts, microbiota and vector competence differ in dengue-2 virus-infected geographically distinct Aedes aegypti populations.Parasites & vectors · 2023Article
- The costs of transgenerational immune priming for homologous and heterologous infections with different serotypes of dengue virus inFrontiers in immunology · 2023Article
- Prohemocytes are the main cells infected by dengue virus in Aedes aegypti and Aedes albopictus.Parasites & vectors · 2022Article
- Dengue Infection Susceptibility of FiveViruses · 2021Article
- Activation of the autophagy pathway decreases dengue virus infection in Aedes aegypti cells.Parasites & vectors · 2021Article
- The effects of DENV serotype competition and co-infection on viral kinetics in Wolbachia-infected and uninfected Aedes aegypti mosquitoes.Parasites & vectors · 2021Article
- In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2).Molecules (Basel, Switzerland) · 2021Article
- Permethrin Resistance inInsects · 2021Article
- Genome-wide identification of Aedes albopictus long noncoding RNAs and their association with dengue and Zika virus infection.PLoS neglected tropical diseases · 2021Article
- Article
- Effect of Oral Infection of Mayaro Virus on Fitness Correlates and Expression of Immune Related Genes inViruses · 2020Article
- Intra-host growth kinetics of dengue virus in the mosquito Aedes aegypti.PLoS pathogens · 2019Article
- Natural Vertical Transmission of Zika Virus in Larval Aedes aegypti Populations, Morelos, Mexico.Emerging infectious diseases · 2019Article
- Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments.Nature communications · 2019Article
- Homologs of Human Dengue-Resistance Genes,Insects · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDengue viruses (DENV) are considered one of the most important emerging pathogens and dengue disease is a global health threat. The geographic expansion of dengue viruses has led to co-circulation of all four dengue serotypes making it imperative that new DENV control strategies be devised.
objectivesHere we characterize dengue serotype-specific innate immune responses in Aedes aegypti and Aedes albopictus using DENV from Puerto Rico (PR).
methodsAe. aegypti and Ae. albopictus were infected with dengue serotype 1 and 2 isolated from Puerto Rico. DENV infected mosquito samples were collected and temporal change in expression of selected innate immune response pathway genes analyzed by quantitative real time PCR.
findingsThe Toll pathway is involved in anti-dengue response in Ae. aegypti, and Ae. albopictus. Infections with PR DENV- 1 elicited a stronger response from genes of the Toll immune pathway than PR DENV-2 in Ae. aegypti but in infected Ae. albopictus expression of Toll pathway genes tended to be similar between the serotypes. Two genes (a ribosomal S5 protein gene and a nimrod-like gene) from Ae. albopictus were expressed in response to DENV. MAIN
conclusionsThese studies revealed a role for antiviral genes in DENV serotype-specific interactions with DENV vectors, demonstrated that infections with DENV-2 can modulate the Toll immune response pathway in Ae. aegypti and elucidated candidate molecules that might be used to interfere with serotype specific vector-virus interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.