ArticlePediatric research2018
Decreased lymphocytes and increased risk for infection are common in endogenous pediatric Cushing syndrome.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- An Overlooked Risk Group in Adult Immunization: Vaccination Awareness and Knowledge in Patients with Cushing's Syndrome: A Cross-sectional Study.Journal of clinical practice and research · 2026Article
- Prognostic nutritional index and inflammatory indices as predictors of perioperative infection in patients with Cushing syndrome: a retrospective single-center study.Frontiers in endocrinology · 2026Article
- Combined surgical excision with skin grafting and thermal therapy for refractory plantar warts: a therapeutic approach in immunocompromised patients.Journal of surgical case reports · 2025Article
- Leukocytosis in Cushing's syndrome persists post-surgical remission and could predict a lower remission prognosis in patients with Cushing's disease.Journal of endocrinological investigation · 2025Article
- Unusual infections and thrombotic events in Cushing's syndrome.Journal of endocrinological investigation · 2025Review
- Inflammation-based scores in a large cohort of adrenocortical carcinoma and adrenocortical adenoma: role of the hormonal secretion pattern.Journal of endocrinological investigation · 2025Article
- Cushing's syndrome and COVID-19.Pituitary · 2024Review
- A novel model using leukocytes to differentiating mild autonomous cortisol secretion and non-functioning adrenal adenoma.Scientific reports · 2024Article
- Article
- Paediatric Cushing syndrome: a prospective, multisite, observational cohort study.The Lancet. Child & adolescent health · 2024Observational
- Adrenal Cushing's syndrome in children.Frontiers in endocrinology · 2023Review
- Prognostic Nutritional Index (PNI) as a Predictor in Patients with Metabolic Syndrome and Heart Failure.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Epidemiology and blood parameter changes in Cushing's syndrome - a population-based study.Hormones (Athens, Greece) · 2022Article
- Inflammatory biomarkers in the evaluation of pediatric endogenous Cushing syndrome.European journal of endocrinology · 2022Article
- Changes in prognostic nutritional index during hospitalization and outcomes in patients with acute heart failure.Heart and vessels · 2022Article
- Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21.The Journal of allergy and clinical immunology · 2022Article
- Glucocorticoid excess and COVID-19 disease.Reviews in endocrine & metabolic disorders · 2021Review
- COVID-19 and the pituitary.Pituitary · 2021Review
- Diagnosis, Manifestations, Laboratory Investigations, and Prognosis in Pediatric and Adult Cushing's Disease in a Large Center in China.Frontiers in endocrinology · 2021Article
- Neutrophil-Lymphocyte Ratio as an Initial Screening Biomarker for Differential Diagnosis of Cushing's Syndrome from Nonfunctional Adenoma in Patients with an Adrenal Mass.BioMed research international · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
BackgroundHypercortisolemia results in changes of the immune system and elevated infection risk, but data on the WBC changes in pediatric Cushing syndrome (CS) are not known. We describe the changes of the WBC lineages in pediatric endogenous hypercortisolemia, their associations with the markers of disease severity, and the presence of infections.MethodsWe identified 197 children with endogenous CS. Clinical and biochemical data were recorded. Sixty-six children with similar age and gender, and normocortisolemia served as controls.ResultsThe absolute lymphocyte count of CS patients was significantly lower than that of controls, while the total WBC and the absolute neutrophil counts were significantly higher. These changes correlated with several markers of CS severity and improved after resolution of hypercortisolemia. Infections were identified in 35 patients (17.8%), and their presence correlated to elevated serum morning cortisol, midnight cortisol, and urinary free cortisol levels, as well as with the decrease in absolute lymphocyte count.ConclusionsChildren with endogenous CS have abnormal WBC counts, which correlate with the severity of CS, and normalize after cure. Infections are common in this population; clinicians should be aware of this complication of CS and have low threshold in diagnosis and treating infections in CS.
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Registered trials
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