Evidence map›Paper›PMID 29211034›Full record

ArticleInternational journal of molecular sciences2017

Glucocorticoids Improve Myogenic Differentiation In Vitro by Suppressing the Synthesis of Versican, a Transitional Matrix Protein Overexpressed in Dystrophic Skeletal Muscles.

Natasha McRae, Leonard Forgan, Bryony McNeill, Alex Addinsall, Daniel McCulloch, Chris Van der Poel, Nicole Stupka

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Treatment of DystrophicBiomolecules · 2020
    Article
  11. Article
  12. Article
  13. Extracellular Matrix in Development and Disease.International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Natasha McRaeSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia. nmcrae@deakin.edu.au.ORCID 0000-0001-6672-0869
Leonard ForganSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia. leonard.forgan@deakin.edu.au.
Bryony McNeillSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia. bryony.mcneill@deakin.edu.au.
Alex AddinsallSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia. aaddinsa@deakin.edu.au.
Daniel McCullochFaculty of Law, The University of Queensland, Brisbane, QLD 4072, Australia. daniel.mcculloch@uq.net.au.
Chris Van der PoelDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC 3086, Australia. c.vanderpoel@latrobe.edu.au.
Nicole StupkaSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia. nicole.stupka@deakin.edu.au.
Deakin University · AULa Trobe University · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Duchenne muscular dystrophy (DMD), a dysregulated extracellular matrix (ECM) directly exacerbates pathology. Glucocorticoids are beneficial therapeutics in DMD, and have pleiotropic effects on the composition and processing of ECM proteins in other biological contexts. The synthesis and remodelling of a transitional versican-rich matrix is necessary for myogenesis; whether glucocorticoids modulate this transitional matrix is not known. Here, versican expression and processing were examined in hindlimb and diaphragm muscles from

Indexed as

Muscle DevelopmentADAMTS1 ProteinAnimalsDiaphragmGlucocorticoidsHEK293 CellsHumansHyaluronan SynthasesMiceMice, Inbred C57BLMice, Inbred mdxMuscular Dystrophy, DuchenneMyoblastsTransforming Growth Factor beta1VersicansADAMTS1 ProteinAdamts1 protein, mouseGlucocorticoidsHas2 protein, mouseHyaluronan SynthasesTransforming Growth Factor beta1VersicansDuchenne muscular dystrophyfibrosisglucocorticoidsmdx mousemyogenesisversican

Identifiers

PMID29211034
PMCPMC5751232
OpenAlexW2771579316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.