ReviewNutrients2017
Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy.
Review in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 7 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- The effect of maternal anemia during pregnancy on low birth weight in Ethiopia; a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Effect of iron supplementation in healthy exclusively breastfed infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Association between anemia in pregnancy with low birth weight and preterm birth in Ethiopia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis.Clinical epigenetics · 2022Pooled it
- Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta-analysis.Annals of the New York Academy of Sciences · 2019Pooled it
- Pooled it
- The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial.Acta obstetricia et gynecologica Scandinavica · 2021Trial
- Trial
- Physical Activity During the Perinatal Period: A Fact Sheet for Clinicians.American journal of lifestyle medicine · 2026Review
- Cortisol Stress Response is Associated with Iron Status in Pregnancy.medRxiv : the preprint server for health sciences · 2026Article
- Micronutrients in Future Diets: Considerations for Dietary Iron and the Food Matrix Effects on Bioavailability.Molecular nutrition & food research · 2026Review
- Research Progress on Ferroptosis Regulation of Female Reproduction.Biological trace element research · 2026Review
- Maternal Prenatal Psychological Stress and Iron Levels in the Fetal Brain.Developmental psychobiology · 2025Article
- Iron status at early pregnancy is associated with infectious respiratory and gastric illness in women receiving routine iron supplementation: the NuPED prospective cohort.BMC pregnancy and childbirth · 2025Article
- The Critical Role of Iron in Pregnancy, Puerperium, and Fetal Development.Journal of clinical medicine · 2025Review
- Fetal Growth Is Associated with Amniotic Fluid Antioxidant Capacity, Oxidative Stress, Minerals and Prenatal Supplementation: A Retrospective Study.Antioxidants (Basel, Switzerland) · 2025Article
- International expert consensus on micronutrient supplement use during the early life course.BMC pregnancy and childbirth · 2025Article
- Association between iron deficiency anemia and severe maternal morbidity: A retrospective cohort study.Annals of epidemiology · 2024Article
- Early life stress and iron metabolism in developmental psychoneuroimmunology.Brain, behavior, & immunity - health · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is particularly important in pregnancy and infancy to meet the high demands for hematopoiesis, growth and development. Much attention has been given to conditions of iron deficiency (ID) and iron deficient anemia (IDA) because of the high global prevalence estimated in these vulnerable life stages. Emerging and preliminary evidence demonstrates, however, a U-shaped risk at both low and high iron status for birth and infant adverse health outcomes including growth, preterm birth, gestational diabetes, gastrointestinal health, and neurodegenerative diseases during aging. Such evidence raises questions about the effects of high iron intakes through supplementation or food fortification during pregnancy and infancy in iron-replete individuals. This review examines the emerging as well as the current understanding of iron needs and homeostasis during pregnancy and infancy, uncertainties in ascertaining iron status in these populations, and issues surrounding U-shaped risk curves in iron-replete pregnant women and infants. Implications for research and policy are discussed relative to screening and supplementation in these vulnerable populations, especially in developed countries in which the majority of these populations are likely iron-replete.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.