Evidence map›Paper›PMID 29210669›Full record

ArticleeLife2017

Extended low-resolution structure of a

Ching-Lin Hsieh, Christopher P Ptak, Andrew Tseng, Igor Massahiro de Souza Suguiura, Sean P McDonough, Tepyuda Sritrakul, Ting Li, Yi-Pin Lin, Richard E Gillilan, Robert E Oswald and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Tropical medicine and infectious disease · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ching-Lin Hsieh *Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Christopher P Ptak *Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.ORCID http://orcid.org/0000-0003-2752-0367
Andrew TsengDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Igor Massahiro de Souza SuguiuraDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Sean P McDonoughDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Tepyuda SritrakulDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Ting LiDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Yi-Pin LinDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, United States.
Richard E GillilanMacromolecular Diffraction Facility at CHESS (MacCHESS), Cornell University, Ithaca, United States.ORCID http://orcid.org/0000-0002-7636-3188
Robert E OswaldDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Yung-Fu ChangDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, United States.ORCID http://orcid.org/0000-0001-8902-3089
Cornell University · USNew York State Department of Health · US

Funding

Overall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5M
NIGMS NIH HHS P41 GM103485
6 · The paper itself

Abstract

Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine design. Here, we use a systematically designed series of multi-domain constructs in combination with small angle X-ray scattering (SAXS) to determine the structure of the main immunoreactive region from a major antigen from

Indexed as

AnimalsAnimal StructuresAntibodies, BacterialAntibodies, MonoclonalAntigens, BacterialBacterial LoadBacterial VaccinesBlood Bactericidal ActivityCricetinaeDisease Models, AnimalLeptospira interrogansLeptospirosisMicrobial ViabilityProtein BindingRecombinant Fusion ProteinsScattering, Small AngleAntibodies, BacterialAntibodies, MonoclonalAntigens, BacterialBacterial VaccinesLigB-m protein, Leptospira interrogansRecombinant Fusion Proteinsbiophysicsinfectious diseaseLigB structuremAb accessibilitymicrobiologystructural biologyvaccine design

Identifiers

PMID29210669
PMCPMC5749957
OpenAlexW2772818540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.