Evidence map›Paper›PMID 29210520›Full record

Trial reportMaternal & child nutrition2018

Supplementation during pregnancy with small-quantity lipid-based nutrient supplements or multiple micronutrients, compared with iron and folic acid, increases women's urinary iodine concentration in semiurban Ghana: A randomized controlled trial.

Seth Adu-Afarwuah, Rebecca T Young, Anna Lartey, Harriet Okronipa, Per Ashorn, Ulla Ashorn, Mamane Zeilani, Kathryn G Dewey

Open access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Maternal & child nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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  4. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.ORCID 0000-0002-2720-5474
Rebecca T YoungProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, California, USA.
Anna LarteyDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Harriet OkronipaDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Per AshornCentre for Child Health Research, University of Tampere Faculty of Medicine and Life Sciences, and Tampere University Hospital, Department of Pediatrics, Tampere, Finland.
Ulla AshornCentre for Child Health Research, University of Tampere Faculty of Medicine and Life Sciences, and Tampere University Hospital, Department of Pediatrics, Tampere, Finland.
Mamane ZeilaniNutriset S.A.S., Malaunay, France.
Kathryn G DeweyProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, California, USA.
University of Ghana · GHTampere University · FIUniversity of California, Davis · USAetna (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is little information on whether prenatal multiple micronutrient (MMN) supplements containing iodine affect women's iodine status. In the International Lipid-based Nutrient Supplements DYAD-Ghana trial, we aimed to assess women's urinary iodine concentration (UIC, μg/L) during pregnancy, as one of the planned secondary outcomes. Women (n = 1,320) <20 weeks of gestation were randomized to consume 60 mg iron and 400 μg folic acid per day (iron and folic acid [IFA]); 18 vitamins and minerals including 250 μg iodine per day (MMN); or 20 g/day of small-quantity lipid-based nutrient supplements (LNS) with the same and additional 4 vitamins and minerals as the MMN (LNS). In a subsample (n = 295), we tested differences in groups' geometric mean UICs at 36 weeks of gestation controlling for baseline UIC and compared the geometric means (approximately median UICs) with the World Health Organization (WHO) cut-offs: median UIC <150, 150-249, and ≥500 reflecting low, adequate, and excessive iodine intakes, respectively. At baseline, overall median UIC was 137. At 36 weeks of gestation, controlling for baseline UIC, geometric mean (95% confidence interval) UICs of the MMN (161 [133, 184]) and LNS (158 [132, 185]) groups did not differ; both values were significantly greater (overall p = .004) than that of the IFA group (116 [101, 135]). The median UICs of the MMN and LNS groups were within the WHO "adequate" range, whereas that of the IFA group was below the WHO adequate range. In this setting, supplementation during pregnancy with small-quantity LNS or MMN providing iodine at the WHO-recommended dose, compared with IFA, increases the likelihood of adequate iodine status.

Indexed as

Dietary SupplementsAdultFemaleFolic AcidGhanaHumansIodineIron, DietaryLipidsMaternal Nutritional Physiological PhenomenaMicronutrientsPregnancyUrban PopulationVitaminsFolic AcidIodineIron, DietaryLipidsMicronutrientsVitaminsiLiNS DYAD-Ghanaiodine intakesmultiple micronutrient capsulespregnant womensmall-quantity lipid-based nutrient supplementsurinary iodine concentration

Identifiers

PMID29210520
PMCPMC5900724
OpenAlexW2772819531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.