ReviewToxicology mechanisms and methods2018
Carcinogenicity of ethylene oxide: key findings and scientific issues.
Review in Toxicology mechanisms and methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Reprocessing of single-use medical devices in cardiology: a systematic literature review of safety and performance characteristics applied to cardiac electrophysiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Pooled it
- Ethylene oxide and risk of lympho-hematopoietic cancer and breast cancer: a systematic literature review and meta-analysis.International archives of occupational and environmental health · 2019Pooled it
- Industrial point source emissions and incident breast and lung cancers: two case-control studies.Cancer causes & control : CCC · 2026Article
- Vitamin D deficiency is associated with elevated blood concentrations of ethylene oxide.BMC public health · 2025Article
- Quantitative structure-activity relationship (QSAR) hazard assessment of the banned pesticides by the National Agency for Food and Drugs Administration and Control.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Association between ethylene oxide exposure and osteoarthritis risk mediated by oxidative stress: evidence from NHANES 2013-2020.Medical gas research · 2025Article
- Exposure to Ethylene Oxide and Relative Rates of Female Breast Cancer Mortality: 62 Years of Follow-Up in a Large US Occupational Cohort.Environmental health perspectives · 2025Article
- Enhanced Bioprinting of 3D Corneal Stroma Patches with Reliability, Assessing Product Consistency and Quality through Optimized Electron Beam Sterilization.Advanced healthcare materials · 2025Article
- Association of ethylene oxide exposure with sex hormones in the general US population: a cross-sectional study.Endocrine connections · 2025Article
- Associations between blood ethylene oxide levels and bone mineral density.Frontiers in public health · 2025Article
- Association between ethylene oxide exposure and osteoarthritis risk among middle-aged and young adults: a cross-sectional study.Frontiers in public health · 2025Article
- Association of ethylene oxide exposure and obstructive sleep apnea.Environmental health and preventive medicine · 2025Article
- Effect of Ethylene Oxide Exposure on Sleep Health: Using NHANES Data from 2015 to 2020.Healthcare (Basel, Switzerland) · 2024Article
- Associations between Ethylene Oxide Exposure and Liver Function in the US Adult Population.Toxics · 2024Article
- Associations of ethylene oxide exposure with depression in American adults.Scientific reports · 2024Article
- Association between blood ethylene oxide levels and the prevalence of periodontitis: evidence from NHANES 2013-2014.Clinical oral investigations · 2024Article
- Association between ethylene oxide exposure and periodontitis: a cross-sectional study from NHANES 2013-2014.BMC public health · 2024Article
- Ethylene oxide exposure increases impaired glucose metabolism in the US general population: a national cross-sectional study.Environmental health and preventive medicine · 2024Article
- Association between blood ethylene oxide levels and periodontitis risk: a population-based study.Frontiers in public health · 2024Article
- Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013-2016.Frontiers in public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed an evaluation of the inhalation carcinogenicity of ethylene oxide (EtO) in December 2016. This article reviews key findings and scientific issues regarding the carcinogenicity of EtO in EPA's Carcinogenicity Assessment. EPA's assessment critically reviewed and characterized epidemiologic, laboratory animal, and mechanistic studies pertaining to the human carcinogenicity of EtO, and addressed some key scientific issues such as the analysis of mechanistic data as part of the cancer hazard evaluation and to inform the quantitative risk assessment. The weight of evidence from the epidemiologic, laboratory animal, and mechanistic studies supports a conclusion that EtO is carcinogenic in humans, with the strongest human evidence linking EtO exposure to lymphoid and breast cancers. Analyses of the mechanistic data establish a key role for genotoxicity and mutagenicity in EtO-induced carcinogenicity and reveal little evidence supporting other mode-of-action hypotheses. In conclusion, EtO was found to be carcinogenic to humans by inhalation, posing a potential human health hazard for lymphoid and breast cancers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.