ArticleInfluenza and other respiratory viruses2018
The effects of the attributable fraction and the duration of symptoms on burden estimates of influenza-associated respiratory illnesses in a high HIV prevalence setting, South Africa, 2013-2015.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The epidemiology of seasonal influenza after the 2009 influenza pandemic in Africa: a systematic review.African health sciences · 2020Pooled it
- The National Burden of Influenza-Associated Respiratory Illness Among Children Aged <5 Years in Niger, 2015-2018.Influenza and other respiratory viruses · 2025Article
- The added value of serologic testing: A comparison of influenza incidence among pregnant persons based on molecular-based surveillance versus serologic testing.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- The attributable fraction of respiratory syncytial virus among patients of different ages with influenza-like illness and severe acute respiratory illness in a high HIV prevalence setting, South Africa, 2012-2016.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Article
- Immunogenicity and Efficacy of Vaccination in People Living with Human Immunodeficiency Virus.Viruses · 2023Review
- The burden of RSV-associated illness in children aged < 5 years, South Africa, 2011 to 2016.BMC medicine · 2023Article
- The national burden of influenza-like illness and severe respiratory illness overall and associated with nine respiratory viruses in South Africa, 2013-2015.Influenza and other respiratory viruses · 2022Article
- Human respiratory syncytial virus diversity and epidemiology among patients hospitalized with severe respiratory illness in South Africa, 2012-2015.Influenza and other respiratory viruses · 2022Article
- Influenza surveillance capacity improvements in Africa during 2011-2017.Influenza and other respiratory viruses · 2021Article
- Influenza disease burden among potential target risk groups for immunization in South Africa, 2013-2015.Vaccine · 2020Article
- An evaluation of the Zambia influenza sentinel surveillance system, 2011-2017.BMC health services research · 2020Article
- Article
- Health and economic burden of influenza-associated illness in South Africa, 2013-2015.Influenza and other respiratory viruses · 2019Article
- Quantifying How Different Clinical Presentations, Levels of Severity, and Healthcare Attendance Shape the Burden of Influenza-associated Illness: A Modeling Study From South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Article
- Prioritization of risk groups for influenza vaccination in resource limited settings - A case study from South Africa.Vaccine · 2019Article
- Article
- The national and provincial burden of medically attended influenza-associated influenza-like illness and severe acute respiratory illness in the Democratic Republic of Congo, 2013-2015.Influenza and other respiratory viruses · 2018Article
- Reply to Alonso et al. "Bangladesh and Rwanda: Cases of high burden of influenza in tropical countries?"Influenza and other respiratory viruses · 2018Article
- The effects of the attributable fraction and the duration of symptoms on burden estimates of influenza-associated respiratory illnesses in a high HIV prevalence setting, South Africa, 2013-2015.Influenza and other respiratory viruses · 2018Article
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Abstract
backgroundThe attributable fraction of influenza virus detection to illness (INF-AF) and the duration of symptoms as a surveillance inclusion criterion could potentially have substantial effects on influenza disease burden estimates.
methodsWe estimated rates of influenza-associated influenza-like illness (ILI) and severe acute (SARI-10) or chronic (SCRI-10) respiratory illness (using a symptom duration cutoff of ≤10 days) among HIV-infected and HIV-uninfected patients attending 3 hospitals and 2 affiliated clinics in South Africa during 2013-2015. We calculated the unadjusted and INF-AF-adjusted rates and relative risk (RR) due to HIV infection. Rates were expressed per 100 000 population.
resultsThe estimated mean annual unadjusted rates of influenza-associated illness were 1467.7, 50.3, and 27.4 among patients with ILI, SARI-10, and SCRI-10, respectively. After adjusting for the INF-AF, the percent reduction in the estimated rates was 8.9% (rate: 1336.9), 11.0% (rate: 44.8), and 16.3% (rate: 22.9) among patients with ILI, SARI-10, and SCRI-10, respectively. HIV-infected compared to HIV-uninfected individuals experienced a 2.3 (95% CI: 2.2-2.4)-, 9.7 (95% CI: 8.0-11.8)-, and 10.0 (95% CI: 7.9-12.7)-fold increased risk of influenza-associated illness among patients with ILI, SARI-10, and SCRI-10, respectively. Overall 34% of the estimated influenza-associated hospitalizations had symptom duration of >10 days; 8% and 44% among individuals aged <5 and ≥5 years, respectively.
conclusionThe marginal differences between unadjusted and INF-AF-adjusted rates are unlikely to affect policies on prioritization of interventions. HIV-infected individuals experienced an increased risk of influenza-associated illness and may benefit more from annual influenza immunization. The use of a symptom duration cutoff of ≤10 days may underestimate influenza-associated disease burden, especially in older individuals.
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