Evidence map›Paper›PMID 29210175›Full record

ArticleJournal of cellular and molecular medicine2018

Site-specific and endothelial-mediated dysfunction of the alveolar-capillary barrier in response to lipopolysaccharides.

Harshavardhan Janga, Liam Cassidy, Fanlu Wang, Dietmar Spengler, Stefanie Oestern-Fitschen, Martin F Krause, Andreas Seekamp, Andreas Tholey, Sabine Fuchs

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  4. HumanTissue barriers · 2024
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  13. The protective role of raltegravir in experimental acute lung injury in vitro and in vivo.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Harshavardhan JangaDepartment of Trauma Surgery and Orthopedics, Experimental Trauma Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany.
Liam CassidySystematic Proteomics & Bioanalytics, Institut für Experimentelle Medizin, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Fanlu WangDepartment of Trauma Surgery and Orthopedics, Experimental Trauma Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany.
Dietmar SpenglerDepartment of Pediatrics, University Medical Center Schleswig- Holstein, Kiel, Germany.
Stefanie Oestern-FitschenDepartment of Trauma Surgery and Orthopedics, Experimental Trauma Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany.
Martin F KrauseDepartment of Pediatrics, University Medical Center Schleswig- Holstein, Kiel, Germany.
Andreas SeekampDepartment of Trauma Surgery and Orthopedics, Experimental Trauma Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany.
Andreas TholeySystematic Proteomics & Bioanalytics, Institut für Experimentelle Medizin, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Sabine FuchsDepartment of Trauma Surgery and Orthopedics, Experimental Trauma Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID 0000-0001-7053-5893
University Hospital Schleswig-Holstein · DEChristian-Albrechts-Universität zu Kiel · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious agents such as lipopolysaccharides (LPS) challenge the functional properties of the alveolar-capillary barrier (ACB) in the lung. In this study, we analyse the site-specific effects of LPS on the ACB and reveal the effects on the individual cell types and the ACB as a functional unit. Monocultures of H441 epithelial cells and co-cultures of H441 with endothelial cells cultured on Transwells

Indexed as

AdultCapillariesCaveolin 1Cell LineCell Membrane PermeabilityCoculture TechniquesElectric ImpedanceEndothelial CellsGene Expression RegulationHumansInflammationLipopolysaccharidesPhosphorylationProteomicsPulmonary AlveoliPulmonary Surfactant-Associated ProteinsCaveolin 1LipopolysaccharidesPulmonary Surfactant-Associated ProteinsTight Junction ProteinsZonula Occludens-1 Proteinalveolar-capillary barrier of the lungepithelial-endothelial crosstalklipopolysaccharidesLiquid chromatography-mass spectrometry-based proteomics

Identifiers

PMID29210175
PMCPMC5783864
OpenAlexW2773972374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.