Evidence map›Paper›PMID 29210126›Full record

ReviewExperimental physiology2018

Crosslink between calcium and sodium signalling.

Alexei Verkhratsky, Mohamed Trebak, Fabiana Perocchi, Daniel Khananshvili, Israel Sekler

Open access · bronzeAbstract readReview
In one paragraph

Review in Experimental physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 82 citations in OpenAlex.

  1. The role of mitochondrial Na⁺/Ca²⁺ exchanger in brain cell aging.Journal of bioenergetics and biomembranes · 2026
    Review
  2. Fluorescence-lifetime optical electrophysiology in contracting cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Sodium regulates PLC and IPPhysiological reports · 2023
    Article
  11. Review
  12. CaFrontiers in physiology · 2023
    Article
  13. Calcium signaling in astrocytes and gliotransmitter release.Frontiers in synaptic neuroscience · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Pharmacological Dissection of the Crosstalk between NaInternational journal of molecular sciences · 2022
    Article
  18. Article
  19. Article
  20. Iron induces two distinct CaCommunications biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0003-2592-9898
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Fabiana PerocchiGene Center/Department of Biochemistry, Ludwig-Maximilians Universität München, Munich, Germany.
Daniel KhananshviliDepartment of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Ramat-Aviv, Israel.
Israel SeklerDepartment of Physiology and Cell Biology, Faculty of Health Science, Ben-Gurion University, Beer-Sheva, Israel.
Ben-Gurion University of the Negev · ILHelmholtz Zentrum München · DEIkerbasque · ESPennsylvania State University · USTel Aviv University · IL

Funding

Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
Genes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471k
NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NIA NIH HHS R21 AG050072
6 · The paper itself

Abstract

NEW

findingsWhat is the topic of this review? This paper overviews the links between Ca ABSTRACT: Transmembrane ionic gradients, which are an indispensable feature of life, are used for generation of cytosolic ionic signals that regulate a host of cellular functions. Intracellular signalling mediated by Ca

Indexed as

AnimalsCalciumCalcium SignalingEndoplasmic ReticulumHomeostasisHumansMitochondriaSodiumCalciumSodiumastrocytesCa2+ signallingmitochondriamitochondrial calcium uniporterNa+-Ca2+ exchangerNa+ signallingneuropathologytransient receptor potential channels

Identifiers

PMID29210126
PMCPMC6813793
OpenAlexW2775518230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.