Evidence map›Paper›PMID 29209830›Full record

ArticleHistochemistry and cell biology2018

Regulation of mesenchymal signaling in palatal mucosa differentiation.

Sanjiv Neupane, Nirpesh Adhikari, Jae-Kwang Jung, Chang-Hyeon An, Sanggyu Lee, Jong-Hwa Jun, Ji-Youn Kim, Youngkyun Lee, Wern-Joo Sohn, Jae-Young Kim

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sanjiv NeupaneDepartment of Biochemistry, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, South Korea.
Nirpesh AdhikariDepartment of Biochemistry, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, South Korea.
Jae-Kwang JungDepartment of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu, South Korea.
Chang-Hyeon AnDepartment of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu, South Korea.
Sanggyu LeeSchool of Life Science and Biotechnology, Kyungpook National University, Daegu, South Korea.
Jong-Hwa JunDepartment of Ophthalmology, School of Medicine, Dongsan Medical Center, Keimyung University, Daegu, South Korea.
Ji-Youn KimDepartment of Dental Hygiene, Gachon University, Incheon, South Korea.
Youngkyun LeeDepartment of Biochemistry, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, South Korea.
Wern-Joo SohnInstitute for Hard Tissue and Bio-tooth Regeneration, Kyungpook National University, Daegu, South Korea. undine75@gmail.com.
Jae-Young KimDepartment of Biochemistry, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, South Korea. jykim91@knu.ac.kr.ORCID http://orcid.org/0000-0002-6752-5683
Kyungpook National University · KRGachon University · KRKeimyung University Dongsan Medical Center · KR

Funding

National Research Foundation of Korea 2010-0004243National Research Foundation of Korea 2012R1A1A2044113National Research Foundation of Korea 2014R1A1A3053711National Research Foundation of Korea 2017R1A5A2015391
6 · The paper itself

Abstract

Epithelial differentiation is thought to be determined by mesenchymal components during embryogenesis. In mice, palatal mucosa showed the region-specific keratinization pattern along antero-posterior axis. However, developmental mechanisms involved in oral mucosa differentiation with fine tuning of keratinization are not elucidated yet. To reveal this developmental mechanism, first, we conducted tissue recombination assay of the palate at E16 for 2 days which revealed that epithelial differentiation with specific localization of CK10 is modulated by mesenchymal components. Based on the results, we propose that mesenchymal signaling would determine the presumptive fate of developing palatal epithelium in spatiotemporal manner. Genome-wide screening analysis using laser micro-dissection to collect spatiotemporal specific molecules between anterior and posterior palate suggested Meox2 in the posterior mesenchymal tissue to be a candidate regulator controlling epithelial differentiation. To examine the detailed spatiotemporal function of Meox2, we employed in vitro organ cultivation with the loss- and gain-of-function studies at E14.5 for 2 and 4 days, respectively. Our results suggest that posteriorly expressed Meox2 modulates non-keratinized epithelial differentiation through complex signaling regulations in mice palatogenesis.

Indexed as

Cell DifferentiationEpithelial-Mesenchymal TransitionSignal TransductionAnimalsGene Expression ProfilingHomeodomain ProteinsKeratin-10MiceMice, Inbred ICRMouth MucosaPalateTissue Culture TechniquesHomeodomain ProteinsKeratin-10Meox2 protein, mouseEpithelial differentiationEpithelial–mesenchymal interactionsGenomewide screeningKeratinisationSignaling regulations

Identifiers

PMID29209830
OpenAlexW2774860663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.