Evidence map›Paper›PMID 29209632›Full record

ArticleJournal of diabetes research2017

Silymarin Ameliorates Diabetes-Induced Proangiogenic Response in Brain Endothelial Cells through a GSK-3

Ahmed Alhusban, Enaam Alkhazaleh, Tamam El-Elimat

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ahmed AlhusbanClinical Pharmacy Department, College of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0000-0003-1105-0620
Enaam AlkhazalehClinical Pharmacy Department, College of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.
Tamam El-ElimatMedicinal Chemistry & Pharmacognosy Department, College of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.
Jordan University of Science and Technology · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a major risk factor for cardiovascular disease. Additionally, it was found to induce a dysfunctional angiogenic response in the brain that was attributed to oxidative stress. Milk thistle seed extract (silymarin) has potent antioxidant properties, though its potential use in ameliorating diabetes-induced aberrant brain angiogenesis is unknown. Glycogen synthase kinase-3

Indexed as

BrainCell LineCell MovementDiabetes MellitusDose-Response Relationship, DrugEndothelial CellsGlycation End Products, AdvancedGlycogen Synthase Kinase 3 betaHumansNeovascularization, PathologicPhosphorylationProtective AgentsProto-Oncogene Proteins c-aktSignal TransductionSilymarinVascular Endothelial Growth Factor AGlycation End Products, AdvancedGlycogen Synthase Kinase 3 betaProtective AgentsProto-Oncogene Proteins c-aktSilymarinVascular Endothelial Growth Factor A

Identifiers

PMID29209632
PMCPMC5676450
OpenAlexW2766831402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.